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Heartworms (Dirofilaria immitis) are parasitic nematodes that cause significant cardiopulmonary-associated morbidity and mortality in canids worldwide. The global dissemination of heartworms is believed to have occurred alongside the dispersal of domesticated dogs. To test this theory, we performed the largest population genetics study of heartworm...
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Context 1
... were observed in a previous study of 31 138 heartworm samples from Australia, Italy, and the USA, where samples from each country 139 formed distinct clusters 21 . Independent PCAs of SNPs from each chromosome found the same 140 continental clustering pattern across all chromosomes, including the sex-linked X chromosome 141 (Extended Data Fig. 2b-f), suggesting that this is a genome-wide rather than region-specific 142 observation. The distinct geographical partitioning in our nuclear data was not supported by 143 the mitochondrial (Extended Data Fig. 3a) or Wolbachia data (Extended Data Fig. 3b), likely 144 due to the few variant sites within each ...
Context 2
... were observed in a previous study of 31 138 heartworm samples from Australia, Italy, and the USA, where samples from each country 139 formed distinct clusters 21 . Independent PCAs of SNPs from each chromosome found the same 140 continental clustering pattern across all chromosomes, including the sex-linked X chromosome 141 (Extended Data Fig. 2b-f), suggesting that this is a genome-wide rather than region-specific 142 observation. The distinct geographical partitioning in our nuclear data was not supported by 143 the mitochondrial (Extended Data Fig. 3a) or Wolbachia data (Extended Data Fig. 3b), likely 144 due to the few variant sites within each ...
