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This whole-brain structural magnetic resonance imaging (MRI) investigation of autism spectrum disorder (ASD) analyzed white and grey matter concentrations, shape differences, and brain microstructure in 20 adolescents with ASD and 10 neurotypical controls. Evidence for significant group-related differences was found in nine regions, most associated...
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Context 1
... increases in WMC were found in the middle temporal gyrus and the superior temporal gyrus on the right. ROIs 17, 18, 19, and 20 correspond (see Figure 3). Significantly lower WMC in the ASD group was found in the right postcentral gyrus, an area that receives the bulk of thalamocortical projections from sensory input fields. ...
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Autism spectrum disorders (ASDs) are neurodevelopmental disorders associated with atypical brain connectivity. Although language abilities vary widely, they are impaired or atypical in most children with ASDs. Underlying brain mechanisms, however, are not fully understood. The present study examined intrinsic functional connectivity (iFC) of the ex...
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Background
Previous studies have reported changes within grey matter (GM) volume in children with autism spectrum disorder (ASD); however, little is known about GM volume changes and the relation with symptom severity in Chinese boys with low functioning autism spectrum disorder (LFASD).
Method
GM volume was analysed using SPM 8 and compared between 16 boys with LFASD as well as 16 typically developing (TD) boys (using REST 1.8). Additionally, the correlation between GM volume and clinical symptoms was analysed, using subscales within the Autism Behaviour Checklist (ABC).
Results
The comparison showed a reduced volume of GM in 11 clusters in the boys with LFASD (i.e., the left inferior frontal gyrus, orbital part; right superior temporal gyrus, superior frontal gyrus, dorsolateral; precuneus and postcentral; bilateral rectus and middle temporal gyrus) and 1 area with increased GM volume (right caudate) compared to the TD group. Additionally, the GM volume of the left inferior frontal gyrus, orbital part was negatively correlated with the Social subscale score of the ABC (r = −0.765, P = 0.002), and the GM volume of the left Rectus was negatively associated with the Language, Body concept and Self‐care subscale scores and the total score on the ABC(r = −0.624, P = 0.023; r = −0.657, P = 0.011; r = −0.618, P = 0.025; r = −0.625, P = 0.022). Further, the GM volume of the right Caudate was negatively correlated with the Sensory subscale on the ABC (r = −0.593, P = 0.033).
Conclusion
In conclusion, the current study's findings display that the GM volume was widely reduced in Chinese boys with LFASD compared to TD boys and negatively correlated with the clinical symptoms, indicating a possible pathological mechanism of LFASD.
