Gene neighborhoods for selected Streptomyces strains and M. tuberculosis. From top Family A, D and E. Rhomboid genes are colored in red and underlined when present.

Gene neighborhoods for selected Streptomyces strains and M. tuberculosis. From top Family A, D and E. Rhomboid genes are colored in red and underlined when present.

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Proteolytic enzymes are ubiquitous and active in a myriad of biochemical pathways. One type, the rhomboids are intramembrane serine proteases that release their products extracellularly. These proteases are present in all forms of life and their function is not fully understood, although some evidence suggests they participate in cell signaling. St...