Gene expression analysis of HUVECs and its coculture on gene-free scaffolds and SDF-1α GAS. SDF-1α GAS significantly increased the expression of mRNAs for SDF-1α and its cognate receptor CXCR4 in HUVECs. Coculture with ADSCs significantly elevated the expression of downstream effector genes of SDF-1α—CXCR4 and eNOS than the HUVECs on SDF-1α GAS. Data are plotted as mean ± standard deviation (n = 3). *, **, and *** indicate statistical significance of p < 0.05, p < 0.01, and p < 0.005, respectively

Gene expression analysis of HUVECs and its coculture on gene-free scaffolds and SDF-1α GAS. SDF-1α GAS significantly increased the expression of mRNAs for SDF-1α and its cognate receptor CXCR4 in HUVECs. Coculture with ADSCs significantly elevated the expression of downstream effector genes of SDF-1α—CXCR4 and eNOS than the HUVECs on SDF-1α GAS. Data are plotted as mean ± standard deviation (n = 3). *, **, and *** indicate statistical significance of p < 0.05, p < 0.01, and p < 0.005, respectively

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Novel biomaterials can be used to provide a better environment for cross talk between vessel forming endothelial cells and wound healing instructor stem cells for tissue regeneration. This study seeks to investigate if a collagen scaffold containing a proangiogenic gene encoding for the chemokine stromal-derived factor-1 alpha (SDF-1α GAS) could be...

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... The lymphangiogenic function increases with infiltrating macrophages that produce (VEGF-C) [35]. In addition to lymphangiogenesis, VEGF-C may regulate physiological angiogenesis [35,36]. Studies have also shown that SIM can suppress the growth of bacterial pathogens [37,38]. ...
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