- Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer’s disease

GAP-43 is associated with faster amyloid-related tau accumulation in meta ROIs Scatterplots illustrating the interaction between amyloid-PET (i.e., centiloid) and CSF GAP-43 levels on tau-PET changes in a global cortical ROI (A), as well as in a temporal meta ROI (B). Regression models were corrected for age, sex, diagnosis, and CSF p-tau181. Note that all interactions were computed using continuous GAP-43 measures across the entire study cohort (N = 93), median split was only performed for visualization. β-values reflect standardized regression weights. All T- and two-sided p-values were derived from linear regression. Linear model fits (i.e., least squares line) are indicated together with 95% confidence intervals displayed as error bands. Source data are provided as a Source Data file. PET Positron Emission Tomography, SUVR Standardized uptake value ratio, CSF cerebrospinal fluid, GAP-43 Growth-associated protein 43.

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Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer’s disease - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/GAP-43-is-associated-with-fasteramyloid-related-tau-accumulation-in-meta_fig2_377114553 [accessed 28 Apr 2025]

Caption

GAP-43 is associated with faster amyloid-related tau accumulation in meta ROIs
Scatterplots illustrating the interaction between amyloid-PET (i.e., centiloid) and CSF GAP-43 levels on tau-PET changes in a global cortical ROI (A), as well as in a temporal meta ROI (B). Regression models were corrected for age, sex, diagnosis, and CSF p-tau181. Note that all interactions were computed using continuous GAP-43 measures across the entire study cohort (N = 93), median split was only performed for visualization. β-values reflect standardized regression weights. All T- and two-sided p-values were derived from linear regression. Linear model fits (i.e., least squares line) are indicated together with 95% confidence intervals displayed as error bands. Source data are provided as a Source Data file. PET Positron Emission Tomography, SUVR Standardized uptake value ratio, CSF cerebrospinal fluid, GAP-43 Growth-associated protein 43.

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<a href="https://www.researchgate.net/figure/GAP-43-is-associated-with-fasteramyloid-related-tau-accumulation-in-meta_fig2_377114553"><img src="https://www.researchgate.net/publication/377114553/figure/fig2/AS:11431281215725251@1704340241917/GAP-43-is-associated-with-fasteramyloid-related-tau-accumulation-in-meta.png" alt="GAP-43 is associated with faster amyloid-related tau accumulation in meta ROIs
Scatterplots illustrating the interaction between amyloid-PET (i.e., centiloid) and CSF GAP-43 levels on tau-PET changes in a global cortical ROI (A), as well as in a temporal meta ROI (B). Regression models were corrected for age, sex, diagnosis, and CSF p-tau181. Note that all interactions were computed using continuous GAP-43 measures across the entire study cohort (N = 93), median split was only performed for visualization. β-values reflect standardized regression weights. All T- and two-sided p-values were derived from linear regression. Linear model fits (i.e., least squares line) are indicated together with 95% confidence intervals displayed as error bands. Source data are provided as a Source Data file. PET Positron Emission Tomography, SUVR Standardized uptake value ratio, CSF cerebrospinal fluid, GAP-43 Growth-associated protein 43."/></a>