Figure - available from: Nature Communications
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Fructose-1,6-biphosphate (F16BP), a glycolytic metabolite, can be formulated into microparticles (MPs) a Schematic representation of F16BP MPs rescuing dendritic cells (DCs) from glycolytic inhibition. b Scanning electron microscopy-energy dispersive X-ray analysis (SEM-EDX) mapping demonstrating the presence of Ca and P in the microparticles. c Scanning electron microscopy image indicating spherical morphology. d Dynamic light scattering (DLS) suggests a size of 2200 ± 300 nm of F16BP MPs.
Source publication
Inhibition of glycolysis in immune cells and cancer cells diminishes their activity, and thus combining immunotherapies with glycolytic inhibitors is challenging. Herein, a strategy is presented where glycolysis is inhibited in cancer cells using PFK15 (inhibitor of PFKFB3, rate-limiting step in glycolysis), while simultaneously glycolysis and func...
