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Frontal View of the Brain Showing the Reticular Formation and the Locus Ceruleus. 

Frontal View of the Brain Showing the Reticular Formation and the Locus Ceruleus. 

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This paper is a discussion of the experience of adult attention deficit hyperactivity disorder (ADHD). While much is known about the diagnosis and treatment of childhood ADHD, therapists may be less familiar with the clinical signs of adult ADHD and fail to detect and address such deficits in patients. Adult ADHD often affects all occupational doma...

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Context 1
... brainstem controls our vegetative functions and houses the reticular formation-the arousal and calming mechanisms of the nervous system. The reticular formation is composed of two systems: (a) the reticular activating system (RAS)-the body's physiologic alarm re- sponse, and (b) the reticular inhibiting system (RIS)-the body's physio- logic stabilizing system (see Figure 2). The RAS acts as a screening device to all incoming sensory data and alerts the brain to attend to im- portant sensory stimuli. People with dysregulation of the reticular for- mation may be unable to screen incoming sensory data in order to distinguish between that which is important and that which is extrane- ous. They may also require significantly increased stimulation to main- tain alertness and arousal. Both of the above are common symptoms of ADHD. A significant body of research has shown that the norepine- phrine (NE) pathways of the reticular formation are compromised in people with ADHD (Pliszka, McCracken, & Maas, 1996). Researchers suggest that overactivation of the NE system in the brainstem may un- derlie an impaired ability to regulate attention and ...
Context 2
... addition to a disorder of the NE system, a number of studies have in- dicated dopaminergic hypoactivity as a prominent factor of ADHD. Al- though the dopaminergic system is widely distributed in the brain, the main dopaminergic projections originate in the substantia nigra and the red nucleus of the midbrain (in the brainstem) (see Figure 2). From the midbrain the dopaminergic pathways project into the basal ganglia, limbic system, and the frontal lobes. It is believed that a dysregulation of the dopamine (DA) system is a primary cause of the impulsivity, hyper- activity, and impaired attention of ADHD. Pharmacologic treatment us- ing stimulant drugs (e.g., methylphenidate and d-amphetamine) increases the amount of DA-and NE-available for brain use. Studies have shown an increased blood flow to the frontal lobes, basal ganglia, and the cere- bellum upon administration of stimulants ( Andreasen et al., 1995;Giedd, Blumenthal, Molloy, & Castellanos, 2001). It appears that the stimulants reactivate dopaminergic pathways-thus regulating the DA system-and facilitate a marked reduction in the symptoms of impulsivity, hyperactiv- ity, and impaired attention (Seeman & Madras, ...
Context 3
... brainstem is also home to the locus ceruleus, located in the rostral pons near the fourth ventricle (see Figure 2). The locus ceruleus is the primary site of NE production and firing. There is substantial ...
Context 4
... brainstem controls our vegetative functions and houses the reticular formation-the arousal and calming mechanisms of the nervous system. The reticular formation is composed of two systems: (a) the reticular activating system (RAS)-the body's physiologic alarm re- sponse, and (b) the reticular inhibiting system (RIS)-the body's physio- logic stabilizing system (see Figure 2). The RAS acts as a screening device to all incoming sensory data and alerts the brain to attend to im- portant sensory stimuli. ...
Context 5
... brainstem is also home to the locus ceruleus, located in the rostral pons near the fourth ventricle (see Figure 2). The locus ceruleus is the primary site of NE production and firing. ...
Context 6
... addition to a disorder of the NE system, a number of studies have in- dicated dopaminergic hypoactivity as a prominent factor of ADHD. Al- though the dopaminergic system is widely distributed in the brain, the main dopaminergic projections originate in the substantia nigra and the red nucleus of the midbrain (in the brainstem) (see Figure 2). From the midbrain the dopaminergic pathways project into the basal ganglia, limbic system, and the frontal lobes. ...

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Citations

... These difficulties, as outlined in the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5; American Psychiatric Association [APA], 2013), fall within two categories: inattention and hyperactivity with impulsivity. Gutman and Szczepanski (2005) proposed that people with ADHD also have considerable difficulty in accessing and modulating their own sensory environment. ...
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... Difficulties with sensory processing may also have an impact on how students in a higher education environment experience that environment and learn. For example, a student with sensory underresponsivity may need background noise when studying to provide the stimulation they need (Gutman & Szczepanski, 2005). Johnson and Irving (2008) explained that transitioning to higher education requires being able to function in a more stimulating environment than previously because students have to cope with larger classes, unfamiliar environments, and life in residence halls with varying levels of noise. ...
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