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We conducted a 16-week double-blind randomized controlled single-center trial to evaluate the safety and efficacy of dermal rice bran supercritical CO, extract (RB-SCE) in the treatment of androgenic alopecia. Fifty alopecia patients were randomly assigned to the experimental and placebo groups. The experimental group received a dermal application...
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... Test tonic products with or without RB-SCE were prepared and kindly supplied by Kolmar Korea (Sinjeong-ri, Yeongi-gun, Chungcheongnam-do, Korea). The studied formulations (Table 1) were prepared in a PRIMIX RM homomixer (PRIMIX Co., Ltd., Japan) at 3000 rpm within 10 min and supplemented with 0.5% (w/w) RB-SCE. A placebo formulation was prepared without RB- SCE. ...
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... O tamanho médio das populações investigadas variou quantitativamente de 40 a 87 indivíduos, com uma média de 63/estudo. Foram incluídos homens e mulheres apenas em três dos estudos (17) (19) (20), entretanto não foi possível correlacionar diferenças entre os gêneros a partir das informações disponibilizadas. As intervenções incluíram aplicações tópicas de formulações à base de plantas e cápsulas de uso oral. ...
... As espécies vegetais terrestres citadas como Intervenção nos estudos foram: Allium sativum L. (19); Oryza sativa L. variedade japonica (arroz) (20); Withania somnifera Dun. (ashwagandha); Serenoa repens (W. ...
... Essas evidências respaldam os óleos essenciais como derivados vegetais que podem ser considerados isoladamente ou em associação para o tratamento da alopecia. O tratamento com extrato de CO2 supercrítico de farelo de O. sativa melhorou o crescimento do cabelo na alopecia androgenética humana sem efeitos colaterais em uma dose moderada, sendo fonte potencialmente promissora de cosméticos funcionais e produtos farmacêuticos para tratar a queda de cabelo de padrão masculino e padrão feminino andrógeno-dependente (20). ...
A alopecia é uma condição caracterizada pela diminuição de pelos ou cabelos que apresenta implicações físicas e psicológicas ao indivíduo. Essa revisão integrativa de literatura investiga os estudos clínicos disponíveis sobre o uso de plantas medicinais, fitoterápicos e/ou suplementos alimentares no tratamento da alopecia. Como bases de dados foram utilizadas: Pubmed, Medline, Web of Science e SciELO. Como estratégia de busca por artigos originais, utilizou-se os descritores: [(alopecia OR baldness OR "hair loss") AND ("Medicinal Plants" OR "Pharmaceutical Plants" OR "Dietary Supplements" OR Nutraceuticals OR "Herbal Supplements") AND (Placebo OR "Effect placebo") AND (hair)]. Os critérios de inclusão utilizados foram estudos clínicos randomizados, duplo-cegos e controlados por placebo, sem limitação de data ou idioma, disponibilizados na íntegra, que incluíssem como intervenção plantas medicinais, ervas medicinais e suplementos alimentares. Os critérios de exclusão foram estudos duplicados, não disponíveis na íntegra e que incluíssem como intervenção suplementos alimentares não vegetais. Verificou-se que os estudos abordaram a alopecia em ambos os sexos, sendo as intervenções aplicadas na forma de uso tópico e oral. Dentre as espécies utilizadas foram verificadas: Allium sativum, Curcuma aeruginosa, Oryza sativa L. variedade japonica, Rosmarinus officinalis, dentre outras. Ressalta-se que estudos adicionais na área ainda são necessários. Cita-se como limitação a carência na abordagem dos aspectos químico-farmacêuticos das espécies utilizadas (análises quali-quantitativas), visto que são fundamentais para o controle da qualidade dos extratos vegetais e consequentemente, para as propriedades terapêuticas reprodutíveis.
... The effectiveness of Rice Bran Supercritical CO2 Extract (RBSCE) for Hair Growth in Androgenic Alopecia was also determined by Choi et al. 26 using folliscopy, demonstrating its value as a phototrichogram and a follow-up technique. 26 In a study to determine the efficiency of scalp shampoo containing extracts from inula helenium (IH) and Caesalpinia sappan bark (CS) on those who have androgenetic alopecia, following use for 16 and 24 weeks, there was a statistically significant rise in hair density and total hair counts. ...
... The effectiveness of Rice Bran Supercritical CO2 Extract (RBSCE) for Hair Growth in Androgenic Alopecia was also determined by Choi et al. 26 using folliscopy, demonstrating its value as a phototrichogram and a follow-up technique. 26 In a study to determine the efficiency of scalp shampoo containing extracts from inula helenium (IH) and Caesalpinia sappan bark (CS) on those who have androgenetic alopecia, following use for 16 and 24 weeks, there was a statistically significant rise in hair density and total hair counts. This indicated that the IH and CS extract complex helped to prevent loss of hair and encourage the growth of hair. ...
... However, there are limitations to its use by both men and women, their effects are inconsistent, and many cases of side effects have been reported, making it difficult to use without burden [4][5][6][7]. To overcome these problems, various natural products and compounds, materials for promoting hair growth and alleviating hair loss symptoms [8,9], a mixture of herbal extracts [10], and their formulations are being developed [11]. ...
PurposeThis double-blind randomized placebo-controlled clinical study aimed to investigate the efficacy and safety of hair loss prevention shampoo with salicylic acid (0.2%), panthenol (0.2%), and niacinamide (0.1%) in alopecia patients.MethodsA total of 42 subjects completed the 24-week clinical study. A series of clinical examinations, counting of the number of hairs number on the crown, and visual and subject survey evaluations were performed at baseline and 8, 16, and 24 weeks after use to evaluate the efficacy and safety of the shampoo for preventing hair loss.ResultsThe primary endpoint was the number of hairs on the crown, which showed a significantly greater increase (17.76%) in the treatment group than in the placebo group at 24 weeks after use (p < 0.05). In the intention-to-treat population, the secondary endpoint, visual evaluation of hair loss symptoms, the crown, the line of forelock, and hair thickness also showed significantly greater increases in the treatment group than in the placebo group (p < 0.05) at 24 weeks after use. Safety evaluations confirmed no abnormal symptoms in the experimental and placebo groups.Conclusions
Therefore, this study suggests that shampoo treatment can help prevent hair loss in patients with alopecia.
... A few studies within the past decade have shown the natural therapeutic potential of rice bran for treating various forms of hair loss, as summarized in Table 3 [54,55,58]. Manosroi et al., demonstrated the potential application of rice bran-based niosomes as a topical therapeutic for androgenic alopecia [54]. ...
... Choi et al. also tested the ability of supercritical carbon dioxide extracted-rice bran to treat androgenic alopecia in a clinical trial [58]. During a double-blind randomized control trial performed over 16 weeks, 25 participants received topical RB-SCE treatment (0.5% RB-SCE or 8 mL/d) while the control group of 25 participants received a placebo [58]. ...
... Choi et al. also tested the ability of supercritical carbon dioxide extracted-rice bran to treat androgenic alopecia in a clinical trial [58]. During a double-blind randomized control trial performed over 16 weeks, 25 participants received topical RB-SCE treatment (0.5% RB-SCE or 8 mL/d) while the control group of 25 participants received a placebo [58]. Their results showed statistically significant increases in total hair count, hair diameter, and overall hair density in male patients receiving the RB-SCE treatment [58]. ...
Background: The impact that hair loss has on an individual's psychological wellness, and subsequent quality of life, is widespread and long lasting. The current standard treatments for hair loss include surgery and medications, ranging from over-the-counter treatments to corticosteroid injections and immunosuppressants. Unfortunately, these current treatments are either expensive, invasive, or have extremely negative side effects. Recently, the role of vitamins, minerals, and functional foods with their associated bioactive compounds, have gained increasing recognition as a potential means to address this issue. Some of these compounds have been shown to decrease the risk of specific forms of hair loss, particularly alopecia, a form of balding that results due from an autoimmune disorder. These include experimental studies using black raspberry extract and egg yolks as well as epidemiological studies using Mediterranean diets and various micronutrients. Other compounds have been shown to promote hair growth on a more general scale, including in vivo studies using rice bran extract and mouse models using red ginseng oil and annurca apple polyphenols. This review identifies key hair growth promoting vitamins, minerals, and functional foods, as well as summarizes the relevant mechanisms of action of these compounds that have been elucidated. Knowledge regarding the effects of these nutriceuticals on reducing hair loss is rapidly expanding. However, it is imperative that further research be done in order to delineate mechanisms of actions for all compounds related to managing and treating hair loss and subsequently integrate these dietary modifications into clinical treatment recommendations for hair loss.Keywords: Hair loss, alopecia, berry extract, mediterranean diet, rice bran, ginseng, annurca apple, thuja orientalis, marine supplement, honey, egg yolk, functional foods, bioactive compounds
... [8] In addition, the same research group carried out the double-blind, randomized experiment on male volunteers for 16 weeks to evaluate the safety and efficacy of rice bran extracted with supercritical CO 2 on hair fall symptoms in the volunteers. [9] The results showed that rice bran extract was able to significantly increase hair density and hair growth in the volunteers without any side effects. ...
Introduction: Riceberry broken rice (RBR) and crude riceberry rice oil (CRO) are inevitably generated from organic rice process in Thailand for several tons per year with low value. The aims of this work were to determine gamma-oryzanol content, fatty acid content, antioxidant activities, total phenolic content (TPC), total flavonoid content (TFC), and tyrosinase-stimulating activity of the extracts from RBR and CRO. Materials and Methods: Different organic solvents were used to extract bioactive compounds from RBR and ethanol was used for CRO. Extracts were analyzed for gamma-oryzanol content by high-performance liquid chromatography and fatty acid content by gas chromatography-mass spectrometry. Their bioactivities were tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), 2,2'-Azino-di(3-ethyl-benzthiazoline sulfonic (ABTS) assays. TPC and TFC assays were performed, and tyrosinase-stimulating activities were also determined. Results: Gamma-oryzanol content in ethanolic CRO (234 mg/100 g) extract was much higher than that in aqueous RBR extract (52.5 mg/100 g). The four isomers of gamma-oryzanol including 24-methylene campesteryl ferulate (51.3%) > campesteryl ferulate (26.0%) > cycloartanyl ferulate (13.1%) > β-sitosteryl ferulate (9.6%) were found in CRO as well as RBR; however in lesser content. Seven fatty acids in the descending order: 41% oleic acid >30% linoleic acid >19% hexadecanoic acid >8% 10-octadecenoic acid >1% 9-octadecenoic acid > 0.6% pentadecanoic acid >0.4% stearic acid were found in CRO and similarly in RBR. Moreover, RBR extract exhibited antioxidant activities at 6.36 mg Trolox Equivalent Antioxidant Capacity (TEAC)/g (DPPH), 1.33 mg FeSO 4 /g (FRAP), 5.82 mg TEAC/g (ABTS) with TPC of 9.94 mg gallic acid equivalent(GAE)/g, and TFC of 67.2 mg catechin equivalent (CE)/g. Interestingly, aqueous RBR extract and ethanolic CRO exhibited 45% and 26% tyrosinase-stimulating activity, respectively. Conclusion: These bioactive compounds and bioactivities in CRO and RBR have a potential to promote hair growth and hair melanogenesis and thus proved useful as cosmetic ingredients in hair product development.
... Rice bran oil and rice bran extracts have been used in the free form and nanoencapsulated for protection against UVB-radiation injuries [3,4], for skin disease treatment [5,6]. Additionally, rice bran bioactive compounds have been found to exert anti-aging activity [7,8] and to be efficient in the treatment of alopecia [9]. Nevertheless, rice water skin benefits are supported by scarce scientific studies and there is a lack of scientific literature unveiling the skin effects largely claimed by cosmetic manufacturers. ...
The skin healing benefits of rice have been known for centuries. Rice (Oryza sativa) water is a food processing waste that can potentially be incorporated into cosmetic formulations. However, no scientific evidence supports their role in skincare products. The aim of this project is to design and develop a topical gel formulation containing rice water and to evaluate its biological properties, namely, the anti-aging and antioxidant rice water properties. Rice water was evaluated in terms of physico-chemical composition and in terms of in vitro biological antioxidant activity and elastase inhibitory effect. Rice water was incorporated into a hydrogel and the developed formulation was subjected to pharmacotechnical tests such as pH and viscosity. Biological and sensory effects were evaluated on a panel of 12 volunteers for 28 days. The safety evaluation study was performed on rice water gel, using the Human Repeat Insult Patch test protocol. Rice water presented in vitro biological antioxidant activity and elastase inhibitory effect. The gel formulation containing 96% rice water was biocompatible with the human skin and presented suitable cosmetic properties. Rice water should be thus considered as an anti-aging ingredient to be used as raw material for skincare applications.
... Studies reported that rice bran extracts (RBE) are potent hair-growth inducer through 5-alpha-reductase inhibition without exhibiting any adverse effects [9,10]. Rice bran oil (RBO) is rich in unsaturated fatty acids (oleic, linoleic, and α-linolenic acids) and saturated fatty acids (palmitic and stearic acids). ...
Objective: The rice bran (RB) phytochemicals are known for several pharmacological properties. The current study aimed to extract the active principles from Thai purple rice bran, formulate the cosmetic products, evaluate the physical property, and stability of the products.Methods: The RB was prepared by 80% ethanolic extraction, and measured the total phenolic and anthocyanin content by HPLC, and spectrophotometric methods. The antioxidant capacity of RB oil (RBO), RB extract (RBE) was assessed by spectrophotometric methods. The cosmetic products were formulated with rice bran extract and fermented and distilled purple rice solution (FDPRS). The stability of the formulations was assessed. The heavy metal and microbial contamination were determined by atomic absorption spectrometry, and plating assay, respectively.Results: The yield of PRE and RBO was 0.92, and 1.62%, respectively. The total phenolic and anthocyanin content of PRE was 305.30 ± 6.15 mg gallic acid/g of extract, and 877.33 ± 87.73 mg cyanidin chloride /g of extract, respectively. RBO, PRE, and FDPRS exhibited high antioxidant capacity. The cosmetic formulations were physically stable in the heat-cool cycle, and the stability of active compounds was not affected while stored at 30°C for two months. The storage temperature affected the phenolic compounds present in the cosmetic formulations, especially at 45°C. There was no significant decrease in oryzanol content of soap formulation. All the formulations were free microbial and heavy metal contamination.Conclusion: The rice bran phytochemical based cosmetic products are rich in antioxidants, stable, free from heavy metals and microbial contaminations, and further fine tuning of the formulation may achieve the market quality.
... Studies reported that rice bran extracts (RBE) are potent hair-growth inducer through 5-alpha-reductase inhibition without exhibiting any adverse effects [9,10]. Rice bran oil (RBO) is rich in unsaturated fatty acids (oleic, linoleic, and α-linolenic acids) and saturated fatty acids (palmitic and stearic acids). ...
Objective: The rice bran (RB) phytochemicals are known for several pharmacological properties. The current study aimed to extract the active principles from Thai purple rice bran, formulate the cosmetic products, evaluate the physical property, and stability of the products.Methods: The RB was prepared by 80% ethanolic extraction, and measured the total phenolic and anthocyanin content by HPLC, and spectrophotometric methods. The antioxidant capacity of RB oil (RBO), RB extract (RBE) was assessed by spectrophotometric methods. The cosmetic products were formulated with rice bran extract and fermented and distilled purple rice solution (FDPRS). The stability of the formulations was assessed. The heavy metal and microbial contamination were determined by atomic absorption spectrometry, and plating assay, respectively.Results: The yield of PRE and RBO was 0.92, and 1.62%, respectively. The total phenolic and anthocyanin content of PRE was 305.30 ± 6.15 mg gallic acid/g of extract, and 877.33 ± 87.73 mg cyanidin chloride /g of extract, respectively. RBO, PRE, and FDPRS exhibited high antioxidant capacity. The cosmetic formulations were physically stable in the heat-cool cycle, and the stability of active compounds was not affected while stored at 30°C for two months. The storage temperature affected the phenolic compounds present in the cosmetic formulations, especially at 45°C. There was no significant decrease in oryzanol content of soap formulation. All the formulations were free microbial and heavy metal contamination.Conclusion: The rice bran phytochemical based cosmetic products are rich in antioxidants, stable, free from heavy metals and microbial contaminations, and further fine tuning of the formulation may achieve the market quality.
... The findings suggest physiological potency of SC-CO 2 extracted RBO as dietary antioxidant supplement. There was a study on the safety and efficacy of SC-CO 2 extracted RBO in the treatment of androgenic alopecia 57 . The results showed that the SC-CO 2 -RBO significantly increased hair density and hair diameter in male subjects with no adverse effects, suggesting a promising use of SC-CO 2 -RBO in the functional cosmetics and pharmaceutical industries 57 . ...
Rice bran is a good source of nutrients that have large amounts of phytochemicals and antioxidants. Conventional rice bran oil production requires many processes that may deteriorate and degrade these valuable substances. Supercritical CO2 extraction is a green alternative method for producing rice bran oil. This work reviews production of rice bran oil by supercritical carbon dioxide (SC-CO2) extraction. In addition, the usefulness and advantages of SC-CO2 extracted rice bran oil for edible oil and health purpose is also described.
... The hair growth-promoting activity of rice bran supercritical CO 2 extract (RB-SCE) and its two components (linoleic acid and γ-oryzanol) were shown using real-time reverse transcriptase-polymerase chain reaction in C57BL/6 mice by Choi et al. [86]. In a double-blinded randomized-controlled study, dermal application of 0.5% of RB-SCE (8 ml/day) to the head skin significantly increased hair density and hair diameter in male patients with alopecia for 16 weeks [88]. ...
