Fig 2 - available from: BMC Complementary and Alternative Medicine
This content is subject to copyright. Terms and conditions apply.
Forest plot of peroneal nerve conduction velocity of YCM on diabetic peripheral neuropathy. Note: PSNCV: peroneal sensory nerve conduction velocity; PMNCV: peroneal motor nerve conduction velocity
Source publication
Abstract Background Various studies have suggested the effectiveness of Chinese medicine in the treatment of diabetic peripheral neuropathy (DPN). There are several principles and methods in Chinese medicine for the treatment of DPN and yang-warming method is one of them. The purpose of this meta-analysis was to review the effectiveness and safety...
Similar publications
The role of traditional Chinese medicine (TCM) on treatment of metastatic colorectal cancer (mCRC) remains controversial, and its active components and potential targets are still unclear. This study mainly aimed to assess the efficacy and safety of TCM in mCRC treatment through meta-analysis and explore the effective components and potential targe...
The efficacy of oral proprietary Chinese medicine in the prevention and treatment of primary osteoporosis was systematically evaluated through a network meta-analysis. The computer retrieved the four major Chinese databases of CNKI, VIP, Wang Fang, CBM in China and abroad, as well as the three English databases and Web of Science of Medline, EMbase...
Background:
Shuxuetong injection (SXT) is a Chinese medicine injection and has been widely used for the treatment of acute myocardial infarction (AMI) in Asia. However, whether SXT has a definite efficacy and safety is poorly understood. The aim of our study was to clarify the effect of SXT on clinical symptoms alliavation and survival in AMI pati...
Background:
Qiliqiangxin (QLQX) capsules are a commonly used proprietary Chinese medicine for the adjuvant treatment of chronic heart failure (CHF) in China. In recent years, several randomized controlled trials (RCTs) have reported on the efficacy and safety of QLQX combined with sacubitril/valsartan for CHF.
Objective:
The purpose of this stud...
Background:
Insomnia has become a universal subhealth disease, affecting more and more modern people's health and quality of life. At present, western medicine is only symptomatic treatment for insomnia. Bailemian Capsule (BLMC) is a proprietary Chinese medicine for treating insomnia. It has been widely used in China, but lacks evidence for eviden...
Citations
... Traditional Chinese medicines (TCM) are of popular choice in [78] countries, especially in China [78]. Several clinical trials have checked the efficiency of TCM therapies in along with EGFR-TKIs [79,80]. Prior execution of the TCM therapy, one should differentiate not only Yin and Yang, cold and heat but also Interior and Exterior, excess and deficiency diseases into 6 meridians and 12 zang-fu organs. ...
... It is quoted in the textbook Huangdi Neijing to differentiate between Yin-cold (YC) and Yang-heat (YH) types of diseases [79]. In another study, it was shown that TCM could be effective in DPN treatment [80]. In a recently published meta-analysis, it was demonstrated that yang-warming Chinese medicines formula alone without western medicines could recover NCV [80]. ...
... In another study, it was shown that TCM could be effective in DPN treatment [80]. In a recently published meta-analysis, it was demonstrated that yang-warming Chinese medicines formula alone without western medicines could recover NCV [80]. This group found a significant difference between the efficacy of western medicines and yang-warming Chinese medicines (p<0.001) ...
Diabetic peripheral neuropathy (DPN) is most crippling
disease worldwide, and its incidences are increasing with
rising prevalence of diabetes mellitus prevalence among
the population. It is causing substantial morbidity and in
severe cases mortality along with posing economic burden. DPN needs a new understanding of its mechanism
and associated clues for pathogenesis. Many biochemical
pathways contribute in progression of DPN such as polyol, hexosamine, advanced glycation end product pathway
etc. Besides the understanding, newer therapies and interventions are emerging, as a strong tool for supporting patient’s healthcare. Apart from conventional therapies, new
therapeutic approaches need to be explored. The present
review is focused on the detailed mechanism of DPN and
newer therapeutic tools for the treatment of DPN in clinics.
... For example, the representative cold TCMs, such as Huanglian (the dried rhizome of Coptis chinensis Franch.), Huangqin (the dried root of Scutellaria baicalensis Georgi), and Dahuang (the dried root and rhizome of Rheum palmatum L.), are extensively used for the treatment of hot syndrome (Xiao et al., 2019), whereas the typical hot TCMs, such as Fuzi (the processed lateral root of Aconitum carmichaelii Debeaux), Ganjiang (the dried Zingiber officinale Roscoe), and Rougui (the dried stem bark of Cinnamomum cassia (L.) J.Presl), are widely used to treat cold syndrome (Panthi et al., 2017). These cold TCMs and hot TCMs can be combined to form cold and hot formulas (Fu-Fang in Chinese) according to compatibility principle. ...
The theory of cold and hot properties is the basic theory of traditional Chinese medicines (TCMs) and has been successfully applied to combat human diseases for thousands of years. Although the theory of cold and hot is very important to guide the clinical application of TCMs, this ancient theory remains an enigma for a long time. In recent years, more and more researchers have tried to uncover this ancient theory with the help of modern techniques, and the cold and hot properties of a myriad of TCMs have been studied. However, there is no review of cold and hot properties. In this review, we first briefly introduced the basic theories about cold and hot properties, including how to distinguish between the cold and hot properties of TCMs and the classification and treatment of cold and hot syndromes. Then, focusing on the application of cold and hot properties, we take several important TCMs with cold or hot property as examples to summarize their traditional usage, phytochemistry, and pharmacology. In addition, the mechanisms of thermogenesis and antipyretic effect of these important TCMs, which are related to the cold and hot properties, were summarized. At the end of this review, the perspectives on research strategies and research directions of hot and cold properties were also offered.
... Patients suffer from pain, psychological pressure, and extra financial burden for a long time, which seriously affects the quality of life of patients. [12,13] In this study, we found that the scores of the quality of life indicators in the intervention group increased significantly after treatment, except for the dimension of VT. However, there was no significant difference before and after treatment in the control group. ...
Objective: The objective of this study is to investigate the effect of mild moxibustion on quality of life of patients with type 2 diabetic peripheral neuropathy (DPN).
Materials and Methods: Fifty-five patients with type 2 DPN from October 2018 to July 2019 were recruited in the present study and randomly divided into two groups: 27 cases in the control group and 28 cases in the intervention group. The control group received routine treatment of hypoglycemic, hypotensive, mecobalamin nutritional nerve, while the intervention group received mild moxibustion on the basis of the control group. The course of treatment for both groups was 10 weeks. The quality of life of the two groups was assessed using short form-36 health survey and compared with t-test at 0.05 significance level.
Results: The total score of the short form-36 in the intervention group was higher than the control group (P < 0.05); the scores of bodily pain, physical functioning (PF), general health (GH), and mental health dimensions in the intervention group increased significantly compared with the control group (P < 0.05); the scores of role physical, social functioning (SF), vitality, and role-emotional (RE) dimensions showed no between-group difference (P > 0.05).
Conclusion: Mild moxibustion can effectively improve the quality of life of patients with type 2 DPN, relieve patient pain symptoms, and improve PF and GH.
Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications in diabetes. Previous studies have shown that chronic neuroinflammation was associated with DPN. However, further research is needed to investigate the exact immune molecular mechanism underlying the pathogenesis of DPN. Expression profiles were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were screened by R software. After functional enrichment analysis of DEGs, a protein–protein interaction (PPI) network analysis was performed. The CIBERSORT algorithm was used to evaluate the infiltration of immune cells in DPN. Next, the least absolute shrinkage and selection operator (LASSO) logistic regression and support vector machine-recursive feature elimination (SVM-RFE) algorithms were applied to identify potential DPN diagnostic markers. Finally, the results were further validated by qRT-PCR. A total of 1308 DEGs were screened in this study. Enrichment analysis identified that DEGs were significantly enriched in immune-related biological functions and pathways. Immune cell infiltration analysis found that M1 and M2 macrophages, monocytes, resting mast cells, resting CD4 memory T cells and follicular helper T cells were involved in the development of DPN. LTBP2 and GPNMB were identified as diagnostic markers of DPN. qRT-PCR results showed that 15 mRNAs, including LTBP2 and GPNMB, were differentially expressed, consistent with the microarray results. In conclusion, LTBP2 and GPNMB can be used as novel candidate molecular diagnostic markers for DPN. Furthermore, the infiltration of immune cells plays an important role in the progression of DPN.
Ethnopharmacological relevance
Zibu Piyin Recipe (ZBPYR) is a traditional Chinese medicine compound composed of 12 kinds of Chinese herbal medicines including red ginseng and yam. Long-term basic and clinical applications have proved that ZBPYR can prevent and treat cognitive dysfunction. Previous studies showed that chronic psychological stress can increase the risk of type 2 diabetes mellitus (T2DM), and lead to cognitive decline. Mitochondrial dysfunction plays a key role in chronic psychological stress-induced diabetes mellitus. While the mechanism of mitochondrial dysfunction and insulin resistance in diabetes-associated cognitive decline (DACD) is unclear.
Aim of the study
Our previous research found that a ZiBuPiYin recipe (ZBPYR) has significant pharmacological effects against DACD. The present study investigated changes in mitochondrial dysfunction in the brain and the mechanism of insulin resistance and mitochondrial damage to explore the relationship between neuronal mitochondrial dysfunction and insulin resistance in chronic psychologically stressed DACD rats.
Materials and methods
Zucker diabetic fatty (ZDF) rats with spontaneous T2DM and rats with diabetic cognitive impairment that was induced by chronic psychological stress were used in in vivo experiments. PC12 cells that were damaged by rotenone were used for the in vitro experiment.
Results
The findings indicated that the number of mitochondria decreased, morphology and membrane potential were damaged, and reactive oxygen species increased in the cortex and hippocampus in psychologically stressed DACD rats. Protein kinase Cβ2 (PKCβ2) activation and insulin resistance were markedly induced by chronic psychological stress, together with decreases in peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and mitochondrial fusion protein 2 (Mfn2). Furthermore, ZBPYR exerted protective effects both in in vivo and in vitro.
Conclusion
Mitochondrial damage and insulin resistance were observed in the brain in chronic psychologically stressed DACD rats. The ZBPYR significantly improved brain mitochondrial damage and insulin resistance in chronic psychologically stressed DACD rats. These results provide novel insights for the development of ZBPYR as a traditional Chinese medicine for the treatment of chronic psychological stress and DACD.
