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Background
To investigate the role of lncRNA LINC00665 in modulating ovarian cancer stemness and its influence on treatment resistance and cancer development.
Methods
We isolated ovarian cancer stem cells (OCSCs) from the COC1 cell line using a combination of chemotherapeutic agents and growth factors, and verified their stemness through western b...
Citations
... The staufen double-stranded RNA binding protein 1 (STAU1), a multifunctional protein primarily involved in mRNA transport and localization, has recently emerged as a potential biomarker in COPD. 4 It has been implicated in various cellular processes, including autophagy and stress responses. Previous studies linked STAU1 to neurodegenerative diseases, where its overexpression was shown to disrupt autophagy and regulate the mechanistic target of rapamycin (mTOR), which plays a critical role in cellular growth and survival. ...
COPD is characterized by chronic inflammation, airway obstruction, and lung damage, often triggered by cigarette smoke. Dysregulated autophagy and inflammation are key contributors to its progression. While STAU1, a multifunctional protein primarily involved in mRNA transport and localization, has been identified as a potential biomarker, its role in COPD pathogenesis remains unclear. This study investigates the effects of STAU1 knockdown on inflammation and autophagy in an in vitro COPD model.We found STAU1 expression was significantly elevated in the in vitro COPD model. Knockdown of STAU1 led to a marked reduction in inflammation in smoke extract-induced BEAS-2B cells. Additionally, STAU1 knockdown suppressed autophagy in smoke extract-induced BEAS-2B cells. Mechanically, it inhibited the activation of the AMPK/mTOR pathway. In summary, STAU1 knockdown inhibits inflammation and autophagy by modulating the AMPK/mTOR axis. Targeting STAU1 could provide new avenues for the treatment of COPD.
