Flow diagram for the evaluation of the accuracy of p16/Ki67 dual-staining cytology testing for the diagnosis of CIN2þ. ADCA, adenocarcinoma; AIS, adenocarcinoma in situ; CIN, cervical intraepithelial neoplasia; CIN2þ, CIN of grade 2 or worse; < CIN2, CIN of grade 1 or negative for dysplasia; HR HPV, high-risk human papilloma virus; SCCA, squamous cell carcinoma.

Contexts in source publication

Context 1

... August 1, 2017, to August 21, 2019, 227 HPV-positive women consented to participate in the study. Fig. 1 shows the flow of the patient selection throughout the study, along with the primary outcomes of CIN2þ. Twelve patients were excluded because of discarded cytology specimens, undergoing colposcopy without biopsy, and inadequate biopsy tissue. In total, 215 patients who had undergone a p16/Ki67 cytology test and colposcopy biopsy ...

Context 2

... patients who had undergone a p16/Ki67 cytology test and colposcopy biopsy completed the study, with a completion rate of 94.7 %. Among the 215 Cobas® HPV test-positive women, 95 (44.2 %) and 120 (55.8 %) had positive and negative p16/Ki67 cytology test results, respectively. The distributions of the test results and outcomes are illustrated in Fig. ...