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![Five main steps of the method for the three modalities used in this study. The data were first acquired from three different databases (Step 1). Then, all neuroimaging data were processed using different software specific to each modality, followed by QC (Step 2). Subsequently, each brain map was parcellated using the Cammoun atlas with 448 cortical regions (Step 3), and the site effect was regressed out using the ComBat software (Step 4). Last, we ensured that each group [participants with an FHAD or with Alzheimer's disease and HCs (when applicable)] had a similar age and men/women proportion at baseline (Step 5).](profile/Christina-Tremblay-2/publication/389570404/figure/fig1/AS:11431281317931887@1742480207267/Five-main-steps-of-the-method-for-the-three-modalities-used-in-this-study-The-data-were.png)
Five main steps of the method for the three modalities used in this study. The data were first acquired from three different databases (Step 1). Then, all neuroimaging data were processed using different software specific to each modality, followed by QC (Step 2). Subsequently, each brain map was parcellated using the Cammoun atlas with 448 cortical regions (Step 3), and the site effect was regressed out using the ComBat software (Step 4). Last, we ensured that each group [participants with an FHAD or with Alzheimer's disease and HCs (when applicable)] had a similar age and men/women proportion at baseline (Step 5).
Source publication
Alzheimer’s disease (AD) is associated with presymptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic biomarkers and a better understanding of AD pathophysiology. AD pathology is thought to arise from a combi...
Contexts in source publication
Context 1
... employed T1-weighted MRI to quantify brain atrophy progression, PET with tau and Aβ radiotracers for mapping Alzheimer-related pathology and diffusion-weighted imaging (DWI) to quantify structural connectivity in FHAD and Alzheimer's disease. Figure 1 provides a summary of the main methodological steps for each of these three modalities. ...
Context 2
... correlations were observed when comparing the baseline atrophy (W-score; r = 0.33, P-value spin = 0.001) and its progression (r = 0.75, P-value spin = 0.001) between Alzheimer's disease and FHAD, suggesting a similar spatial pattern (Zou's CI: −0.51 to −0.33). However, post hoc comparisons between Alzheimer's disease and FHAD revealed that 12 regions exhibited greater atrophy progression (+β value) in Alzheimer's disease and, 80 regions, predominantly located in the temporal, frontal and parietal cortices, demonstrated less atrophy progression with age (−β value) ( Supplementary Fig. 1). Overall, these results demonstrate that FHAD subjects show atrophy in regions also affected in Alzheimer's disease, although with a less severe and widespread pattern. ...
