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The health impact of prolonged space flight on the human body is not well understood. Liquid biopsies based on cell-free DNA (cfDNA) or exosome analysis provide a noninvasive approach to monitor the dynamics of genomic, epigenomic and proteomic biomarkers, and the occurrence of DNA damage, physiological stress, and immune responses. To study the mo...
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... thermal profile for detecting mtDNA was carried out as follows: an initiation step for 2 min 461 at 50°C is followed by a first denaturation step for 10 min at 95°C and a further step consisting of 462 40 cycles for 15 s at 95°C and for 1 min at 60°C. MtDNA levels in all of the plasma analyses were (Figure 1) and for the mitochondrial genome (Figure 2) for all samples were generated 494 using the R package ggplot2. CC-BY-NC-ND 4.0 International license available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. ...Similar publications
Liquid biopsies based on cell-free DNA (cfDNA) or exosomes provide a noninvasive approach to monitor human health and disease but have not been utilized for astronauts. Here, we profile cfDNA characteristics, including fragment size, cellular deconvolution, and nucleosome positioning, in an astronaut during a year-long mission on the International...
