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Background: Ethanolic extracts from P. peruviana showed cytotoxic activity against different cancer cell lines. Objective: To evaluate the antiproliferative activity of aqueous extract of the fruit golden berryin colon cancer cells. Materials and Methods: We analyzed cytotoxicity and selectivity index (SI) (MTT), antiproliferation (sulforhodamine-B...
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... The extract also induced apoptosis and increased the expression of TRAIL-DR4/-DR5 receptors and caspase-3 activation in both cell lines. In addition, the extract had an impressive level of antioxidant activity and also contained high levels of flavonoids and carotenoids (Mazo et al., 2013). Most importantly, withanolides from goldenberry include more than 300 natural C-28 steroidal lactones with antitumor properties against breast cancer (Yu et al., 2021) and hepatocellular carcinoma (Yen et al., 2010). ...
... The anti-cancer properties of extracts from P. peruviana whole plant and its individual organs have been studied on in vitro models, revealing a high anti-proliferative potential on several human cancer cell lines including colon (Demir, Özen, & Hameş-Kocabaş, 2014;Wu et al., 2009;Wu, Ng, Chen, et al., 2004;. In a previous work (Areiza-Mazo, Maldonado, & Rojano, 2013), the anti-proliferative and apoptogenic activities of an aqueous extract from P. peruviana fruit were determined against SW480 (IC 50 = 44.20 µg/mL) and SW620 (IC 50 = 85.10 µg/mL). Furthermore, the anti-cancer effect of a methanolic extract from P. peruviana twigs was also evaluated against HCT116 cells showing an important activity (IC 50 = 12.26 µg/ mL) (Mbaveng et al., 2018). ...
A comprehensive Foodomics study was carried out in this work to investigate the changes induced at gene and metabolite expression levels on HT29 colon cancer cell lines upon treatment with a bioactives-enriched extract from goldenberry calyx. As a result of the proposed multi-omics approach, the tested extract induced transcriptional activation of pro-apoptotic genes, and altered the expression of several genes related to the oxidative stress response in treated cancer cells. Metabolomics data confirm altered cellular redox homeostasis, providing additional evidence to transcriptomic results. Foodomics data integration also revealed alteration on relevant metabolic processes, suggesting inactivation of aminoacyl tRNA charging pathway, dysfunction on carnitine shuttle and beta-oxidation of fatty acids, and pyrimidine ribonucleotide interconversion impairment. These observations are in line with functional analysis and anti-proliferative activity results, where the viability of HT-29 colon cancer cells was notably reduced after 48 h treatment without affecting the viability of normal human colon fibroblast cells.
Tropical fruit by-products can be considered a reservoir of bioactive substances with promising benefits on human's health. In recent years, the recovery of bioactive compounds from agro-food by-products is an emerging trend in food science that largely contributes to the valorization of food industrial processing generated wastes. In this chapter, a general overview about the potential of tropical fruits by-products as sources of bioactive compounds will be provided under a Foodomics perspective. The integration of advanced extraction procedures, along with multi-analytical and multi-omics platforms for the development of tropical fruit by-products valorization strategies are reviewed in this chapter.
