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- Patient Age-Associated Mortality Risk Is Differentiated by BRAF V600E Status in Papillary Thyroid Cancer

Fig A1. Multivariate Cox proportional hazards regression analysis of mortality risk with restricted cubic splines (RCS) in patients with conventional papillary thyroid cancer (CPTC). (A) A continuous and nearly linear association between patient age and CPTC-specific mortality was observed in all patients. (B) The association was linear and even steeper in patients with BRAF V600E mutation. (C) A linear association was not seen in patients with wild-type BRAF. The blue line represents the fitted line of the association between patient age and the estimated hazard ratio (HR) of mortality risk after adjustment; the shaded region represents the 95% CI. The models were adjusted for the following clinicopathologic characteristics: patient sex, tumor size, extrathyroidal extension, lymph node metastasis, distant metastases, administered activities of radioactive iodine, and study center. The RCS plots were performed with the age of 45 years as the reference for HR calculation. (D) Specific HRs and 95% CIs were calculated for the indicated age points. (*) Significantly different HRs in reference to patient age of 45 years. Because of the small number of deaths in patients younger than age 45 years, there were large variations in log HRs in patients with CPTC harboring only wild-type BRAF in the young age ranges. Consequently, different y-axis scales are used for log HR for panels A, B, and C. 
Fig A1. Multivariate Cox proportional hazards regression analysis of mortality risk with restricted cubic splines (RCS) in patients with conventional papillary thyroid cancer (CPTC). (A) A continuous and nearly linear association between patient age and CPTC-specific mortality was observed in all patients. (B) The association was linear and even steeper in patients with BRAF V600E mutation. (C) A linear association was not seen in patients with wild-type BRAF. The blue line represents the fitted line of the association between patient age and the estimated hazard ratio (HR) of mortality risk after adjustment; the shaded region represents the 95% CI. The models were adjusted for the following clinicopathologic characteristics: patient sex, tumor size, extrathyroidal extension, lymph node metastasis, distant metastases, administered activities of radioactive iodine, and study center. The RCS plots were performed with the age of 45 years as the reference for HR calculation. (D) Specific HRs and 95% CIs were calculated for the indicated age points. (*) Significantly different HRs in reference to patient age of 45 years. Because of the small number of deaths in patients younger than age 45 years, there were large variations in log HRs in patients with CPTC harboring only wild-type BRAF in the young age ranges. Consequently, different y-axis scales are used for log HR for panels A, B, and C. 
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