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Correlations of the maximum contraction responses of varicose and control vein segments as measured in vitro for (a) NA; and (b) 5-HT to time to return to 10% of resting diameter as measured in vivo.

Correlations of the maximum contraction responses of varicose and control vein segments as measured in vitro for (a) NA; and (b) 5-HT to time to return to 10% of resting diameter as measured in vivo.

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The content of circulating endothelial cells in the blood, taken from the ulnar vein in 127 patients suffering from chronic varicosity of lower limbs, referring to different classes of chronic venous insufficiency, has been studied. To evaluate the state of deep veins, the patients underwent an instrumental examination. As a result of the performed investigation it has been established that the patients with varicosity of lower limbs have an increased level of the circulating endothelial cells level in the blood. Their content increases in chronic venous insufficiency progression, which may testify to a more marked lesion of the endothelial layer of the venous wall. The content of the circulating endothelial cells in the blood also depends on the type of hemodynamic disturbances developing in the lower limbs veins. It has been found out that the determination of the CEC level can be an additional diagnostic criterion for the severity of chronic venous insufficiency and it can be used to predict the nature of the disease course.