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Effect of sulforaphane on thermal (A) and mechanical (B) hyperalgesia in diabetic rats. Thermal hyperalgesia to both hot (45ºC) and cold (10ºC) stimuli were studied using tail immersion test and for quantifying mechanical hyperalgesia von Frey anesthesiometer and Randall Selitto callipers were employed. Sulforaphane resulted in a significant alleviation of mechanical hyperalgesia at both dose levels. However, thermal hyperalgesia, was corrected only with higher dose of sulforaphane i.e. 1 mg/kg. ND: non diabetic; STZ-D: Diabetic; D+SFN 0.5 and D+SFN 1: Diabetic group treated with sulforaphane 0.5 and 1 mg/kg respectively. Results are expressed as Mean ± SEM; ### p<0.001 Vs ND; ** p<0.01 and *** p<0.001 Vs STZ-D (n= 6).
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