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Fasted-State Simulated Intestinal Fluid (FaSSIF) Composition FaSSIF

Fasted-State Simulated Intestinal Fluid (FaSSIF) Composition FaSSIF

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This literature review is a compilation of the composition and, in most cases, the preparation instructions for simulated biological fluids that may be used as dissolution media in the evaluation of dissolution profiles and amount of drug released from pharmaceutical dosage forms. The use of simulated biological fluids can give a better understandi...

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Context 1
... recent data in humans indicate that the pH in the upper small intestine decreases rather slowly after meal intake (Table 6) (13,14). ...
Context 2
... the fasted state, FaSSIF (Table 5) is suitable. For the fed state, an improved composition was developed (see FeSSIF-V2 in Table 6) (13,14). ...

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