Figure 1 - uploaded by Jordan R. Yaron
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Fabrication and characterization of insoluble, tunable silk fibroin wound dressings. (A) FT-IR spectra of purified silk fibroin with key peaks indicated for amide I (1650 cm-1), amide II (1520 cm-1), and amide III (1240 cm-1). (B) Representative 6-mm diameter silk wound dressing. (C) SEM of top surface (“top”) and cross-section (“cross”) of insoluble silk dressing at 10,000x. Scale bar = 1 µm. (D) DMA results for Storage Modulus, Loss Modulus, and Tan(δ) of insoluble silk dressing. (E) 40-day swelling study of 4 mL (60-µm thick) and 8 mL (120-µm thick) cast silk dressings. Results are shown as mean ± standard error. Statistics are performed by two-way ANOVA with Fisher’s LSD. *p<0.05.
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The inflammasome is a multiprotein complex critical for the innate immune response to injury. Inflammasome activation initiates healthy wound healing, but comorbidities with poor healing, including diabetes, exhibit pathologic, sustained activation with delayed resolution that prevents healing progression. In prior work, we reported the allosteric...
