FIGO leiomyoma subclassification system. Note: Reprinted from Int J Gynaecol Obstet. Vol 113(1). Munro MG, Critchley HO, Broder MS, Fraser IS, FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COeIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Pages 3–13. Copyright 2011, with permission from elsevier. 1 Abbreviation: FIGO, International Federation of Gynecology and Obstetrics.  

FIGO leiomyoma subclassification system. Note: Reprinted from Int J Gynaecol Obstet. Vol 113(1). Munro MG, Critchley HO, Broder MS, Fraser IS, FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COeIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Pages 3–13. Copyright 2011, with permission from elsevier. 1 Abbreviation: FIGO, International Federation of Gynecology and Obstetrics.  

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A debate among gynecologic and reproductive surgeons is whether or not there is a clinical need to treat all intramural myomas. Considerations include myoma size and number, ability to access them, whether or not they compromise the endometrium, and treatment effect on gynecologic, reproductive, and obstetric outcomes. We conducted a detailed study...

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... The prevalence of intramural type of leiomyoma is well documented. Intramural myomas are the most prevalent of all the leiomyomas [24]. ...
... It is prevalent in women of childbearing age but can also occur after menopause. Intramural fibroids are the most common kind and can appear as single or multiple tumors [9]. Patients usually present with irregular heavy periods and subsequently may develop IDA. ...
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Iron deficiency anemia (IDA) accounts for roughly half of all anemia cases globally. Menorrhagia and menstrual cycle disorders render women of childbearing age more prone to IDA. One of the leading causes of menorrhagia is uterine fibroids (leiomyomas), which are defined as hyperplastic, usually benign, overgrowths of uterine wall muscle and connective tissue. This is a case report of a 45-year-old woman who came to the emergency department complaining of progressive fatigue and dizziness for two months. She was admitted as a case of life-threatening IDA with a hemoglobin level of 3.0 g/dL. She was ambulatory and hemodynamically stable without any features of severe anemia. Pelvic ultrasound was performed and revealed uterine fibroids. After partial correction of the anemia, she underwent a total hysterectomy as a definitive treatment.
... Uterine myomas have been classifi ed according to their general uterine position: submucous, intramural, and subserosal. 15 Intramural myomas are the most prevalent of all the leiomyomas. Two-dimensional transvaginal sonography detected a 58%-79% occurrence of intramural myomas among study populations with observable myomas. ...
... 16 In a multicenter retrospective study involving two-dimensional transvaginal sonography, MRI, and LUS, intramural myomas comprised 58% of all myomas imaged, regardless of the imaging method used. 15 Most of the locations of uterine fi broids in this study are intramurally followed by submucosal and subserosal. ...
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Objective: To investigate the correlation of serum Vascular Endothelial Growth Factor (VEGF) levels and uterine fi broid volume. Methods: Observational analytic study was carried out on 80 patients with uterine fi broids indicated myomectomy. Each sample was examined for VEGF levels and volume of myoma tissue post myomectomy was measured by using Archimedes' law. Correlation test using the Spearman test. Results: A total of 80 samples of patients were examined for VEGF levels and uterine fi broids volume. The median VEGF is 360 pg/mL, the median uterine fi broids volume is 325 ml. The Spearman'stest shows p values (<0.01) and r (0.999). Conclusions: There is a signifi cant correlation between VEGF levels and uterine fi broids volume. The higher the VEGF level, the greater the volume of uterine fi broids.
... Uterine myomas have been classifi ed according to their general uterine position: submucous, intramural, and subserosal. 15 Intramural myomas are the most prevalent of all the leiomyomas. Two-dimensional transvaginal sonography detected a 58%-79% occurrence of intramural myomas among study populations with observable myomas. ...
... 16 In a multicenter retrospective study involving two-dimensional transvaginal sonography, MRI, and LUS, intramural myomas comprised 58% of all myomas imaged, regardless of the imaging method used. 15 Most of the locations of uterine fi broids in this study are intramurally followed by submucosal and subserosal. ...
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Background: Tumor size is related to variations associated with molecular markers. In recent years, it has been reported that investigation of tumor volume has become very popular. Measurement of uterine fibroids volume is very important for treatment response. Objective: The aims of this study is to find the correlation of VEGF levels and uterine fibroids volume. Methods: Observational analytic study was carried out on 80 patients with uterine fibroids indicated myomectomy. Each sample was examined for VEGF levels and volume of myoma tissue post myomectomy was measured by using Archimedes' law. Correlation test using the Spearman test. Results: A total of 80 samples of patients were examined for VEGF levels and uterine fibroids volume. The median VEGF is 360 pg/mL, the median uterine fibroids volume is 325 ml. The Spearman’s test shows p values ​​(<0.01) and r (0.999). Conclusion: There is a significant correlation between VEGF levels and uterine fibroids volume. The higher the VEGF level, the greater the volume of uterine fibroids. Keywords: VEGF, uterine fibroids volume, Archimedes law *Corresponding author: Rajuddin e-mail: rajuddin@unsyiah.ac.id dan Ronald_drozz@yahoo.com
... As per the study by Mayra J Thompson et.al 2016, it is reported in the literature the need to manage intramural myomas and to treat them appropriately. 18 As the size of the fibroid was 13*15mm, it could have been selflimiting, but for the bothering symptoms of menorrhagia. Hence, it was decided to administer the Ayurvedic medicines available in the Outpatient department such as Ashokarista, Pushyanuga churna & Chandraprabhavati. ...
... As per the study by Mayra J Thompson et.al 2016, it is reported in the literature the need to manage intramural myomas and to treat them appropriately. 18 As the size of the fibroid was 13*15mm, it could have been selflimiting, but for the bothering symptoms of menorrhagia. Hence, it was decided to administer the Ayurvedic medicines available in the Outpatient department such as Ashokarista, Pushyanuga churna & Chandraprabhavati. ...
... ний к консервативной миомэктомии при узлах интрамуральной локализации -предмет дискуссий. В перечень показаний к миомэктомии включают размеры узлов (от 4 до 5 см), их количество, наличие деформации полости матки, общий объем матки [40,[44][45][46]. В Российской Федерации показания к консервативной миомэктомии перед планированием методов ВРТ регламентированы в соответствии с п. 19 приказа Министерства здравоохранения РФ № 107н (30 августа 2012 г.): показано удаление миоматозных узлов диаметром более 4 см. ...
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The aim of this review is to estimate etiologic role of uterine fibroids in female infertility; it based on the results of current studies of infertility in various cases of fibroids (submucous, intramural and subserous). In article was analyzed the efficiency of the treatment of infertility in women with uterine myoma in IVF programs. Conclusion : a detailed study of endometrial receptivity in women with uterine fibroids is necessary to for personalized strategy in patients with uterine fibroids (myoma) and infertility.
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Objective: To explore the impact of FIGO type 3 fibroids on the outcomes of in vitro fertilization (IVF) cycles. Study design: This is a nested retrospective case-control study. Women with FIGO type 3 intramural fibroids, who underwent the first IVF cycle between January 2010 and December 2016 were included in the study as fibroids group. Patients in control group were randomly selected from a general IVF cohort by a ratio of 2:1 with fibroids group, matched by age, BMI, type and cause of infertility and antral follicle count. Implantation rate (IPR), clinical pregnancy rate (CPR), miscarriage rate (MR), and live birth rate (LBR) were compared between groups. Results: A total of 97 women comprised the fibroids group. Additional 194 women with normal uterus were included in the control group. While baseline characteristics did not differ between the groups, women with FIGO type 3 intramural fibroids showed significantly lower IPR (15.7 % vs. 24.6 %, p = 0.015), CPR (23.7 % vs. 38.1 %, p = 0.014) and LBR (16.5 % vs. 30.4 %, p = 0.011) compared with non-fibroid controls. No difference was observed in MR (p > 0.05). Fibroids of a maximum diameter ≥30 mm or multiple (≥2) fibroids decrease the IPR, CPR and LBR compared with the control group, while the smaller ones or single fibroid has no impact on IVF outcomes. Conclusions: FIGO type 3 fibroid ≥30 mm or multiple fibroids might exert deleterious impact on implantation, clinical pregnancy and live birth rate of IVF cycles.
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Objective This meta-analysis aimed to perform a meta-analysis including randomized controlled trials (RCTs) to assess the efficiency and safety of tranexamic acid (TXA) for reducing blood loss and transfusion requirements in patients undergoing open myomectomy. Methods A systematic search was performed in Medline (1966–2017.03), PubMed (1966–2017.03), Embase (1980–2017.03), ScienceDirect (1985–2017.03,) and the Cochrane Library. Study evaluated the efficiency and safety of TXA in myomectomy was selected. Meta-analysis was performed using Stata 11.0 software. Results Four RCTs including 328 patients met the inclusion criteria. The present meta-analysis indicated that there were significant differences between groups in terms of total blood loss (standard mean difference [SMD] = −1.512, 95% confidence interval [CI]: −2.746 to −0.278, P = .016), postoperative hemoglobin level (SMD = 0.650, 95% CI: 0.045–1.255, P = .035), transfusion requirements (SMD = −0.102, 95% CI: −0.199 to −0.006, P = .038), and duration of surgery (SMD = −0.514, 95% CI: −0.749 to −0.280, P = .000). In addition, no adverse effect was identified in treatment groups. Conclusions Intravenous administration of TXA in open myomectomy was associated with significantly reduced total blood loss, postoperative hemoglobin decline, duration of surgery, and transfusion requirements. Based on the limitations of the current meta-analysis, high-quality RCTs with long-term follow-up are still required.