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Effect of methanolic extract of Luffa cylindrica leaf on alkaline phosphatase activity in the liver, kidney, spleen and serum of mice

Effect of methanolic extract of Luffa cylindrica leaf on alkaline phosphatase activity in the liver, kidney, spleen and serum of mice

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Introduction: Luffa cylindrica is a plant used in folk medicine of Nigeria to treat malaria. Safety evaluation of methanolic leaves extract of Luffa cylindrica was carried out in selected organs of mice at the doses of 50, 100, 200, 400 and 800 mg/kg body weight (b.w). Methodology: Thirty albino mice were completely randomized into six groups consi...

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... in the kidney and spleen of rats when compared to the control. Similarly, a significant decrease (p < 0.05) in ALP activity was observed in the liver of rats that received the extract doses of 100, 200, 400 and 800 mg/kg. This decrease in ALP activity further resulted to a concomitant increase in the activity of ALP in the serum of the animals (Fig. 4). The effect of administration of methanolic leaves extract of L. cylindrica on kidney and liver function indices are presented in Tables 1 and 2 respectively. Concentration of urea significantly (p < 0.05) decreased while there was no significant alteration (p < 0.05) observed in the concentration of creatinine in rats after treatment ...

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