Effect of extracts on keratinocyte (HaCaT) migration with the scratch assay from 0 h to 48 h of incubation: (A) untreated cells as control; (B) cells treated with T. nelsonii extract. Cellular proliferation and migration started at 6 and 12 h, respectively; (C) cells treated with A. americana extract. The wound closure area at 48 h was the same for rows A and B; (D) cells treated with A. vera gel. Cellular migration was observed to begin at 12 h. Dotted lines delineate the wound edges. Keratinocyte migration was photographed using an inverted microscope at a X10× magnification.

Effect of extracts on keratinocyte (HaCaT) migration with the scratch assay from 0 h to 48 h of incubation: (A) untreated cells as control; (B) cells treated with T. nelsonii extract. Cellular proliferation and migration started at 6 and 12 h, respectively; (C) cells treated with A. americana extract. The wound closure area at 48 h was the same for rows A and B; (D) cells treated with A. vera gel. Cellular migration was observed to begin at 12 h. Dotted lines delineate the wound edges. Keratinocyte migration was photographed using an inverted microscope at a X10× magnification.

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Currently, there are various physical and mechanical agents that can cause skin wounds, which are still traditionally treated with plant extracts. It has been reported that the genus Tagetes has a wide range of biological properties, including antibacterial and wound healing activity. Likewise, Agave americana extract and Aloe vera gel have shown p...

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