Figure - available from: Neurochemical Research
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Effect of clemastine on neurobehavior and motor coordination. Representative graph of (A) Neurological deficit score; Rotarod at (B) 5 RPM, (C) 10 RPM and (D) 20 RPM; (E) Y maze; (F) NORT; and elevated plus maze (G) open arm, (H) closed arm. Data are expressed as mean ± SD and analyzed for statistical significance using two-way ANOVA with Bonferroni test ***p < 0.001, **p < 0.01, *p < 0.5 vs. Sham; ###p < 0.001, ##p < 0.01, # p < 0.5 vs. Stroke group (n = 6, each group)
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The progressive brain damage following ischemic stroke is primarily due to oxidative stress and activation of inflammatory pathways. Post-stroke neurodegeneration can lead to the loss of neurons and glial cells, including oligodendrocytes, contributing to demyelination. Following ischemic stroke, reperfusion results in increased intracellular calci...
