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Effect of administration of methanolic extract of Luffa cylindrica leaf on aspartate aminotransferase activity in the liver, kidney, spleen and serum of mice

Effect of administration of methanolic extract of Luffa cylindrica leaf on aspartate aminotransferase activity in the liver, kidney, spleen and serum of mice

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Introduction: Luffa cylindrica is a plant used in folk medicine of Nigeria to treat malaria. Safety evaluation of methanolic leaves extract of Luffa cylindrica was carried out in selected organs of mice at the doses of 50, 100, 200, 400 and 800 mg/kg body weight (b.w). Methodology: Thirty albino mice were completely randomized into six groups consi...

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... effect of administration of methanolic leaves e x t r a c t o f L . c y l i n d r i c a o n a s p a r t a t e aminotransferase is presented in Fig. 1. A significant decrease (p < 0.05) in the activity of aspartate aminotransferase was observed in the liver, kidney and spleen of rats at all the doses compared to the control. Whereas, in the serum of rats, activity of AST significantly (p < 0.05) increased following the administration of the extract at all the doses when compared to ...

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