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Effect of administration of methanolic extract of Luffa cylindrica leaf on alanine aminotransferase activity in the liver, kidney, spleen and serum of mice

Effect of administration of methanolic extract of Luffa cylindrica leaf on alanine aminotransferase activity in the liver, kidney, spleen and serum of mice

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Introduction: Luffa cylindrica is a plant used in folk medicine of Nigeria to treat malaria. Safety evaluation of methanolic leaves extract of Luffa cylindrica was carried out in selected organs of mice at the doses of 50, 100, 200, 400 and 800 mg/kg body weight (b.w). Methodology: Thirty albino mice were completely randomized into six groups consi...

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... administration of the extract at all the doses when compared to the control. The extract at the end of the 7 days of treatment, significantly (p < 0.05) decreased the activity of alanine aminotransferase at 50, 100, 200, 400 and 800 mg/kg b.w in all the organs and a concomitant decrease of ALT activity in the serum when compared to the control (Fig. 2). GGT activity decreased significantly (p < 0.05) at all doses in the spleen but only at 200, 400 and 800 mg/kg b.w in the liver of rats, when compared to the control. Contrary to what was observed in the liver and spleen, GGT activity significantly (p < 0.05) increased in the serum of rats at all the doses when compared to the control ...

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