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Effect of administration of aqueous extract of VPX stem bark on serum lipid profile of STZ-induced diabetic rats VPX = Vitellaria paradoxa Each bar is a mean of five replicates ± S.E.M. Error bars with different superscripts are statistically different (p < 0.05).

Effect of administration of aqueous extract of VPX stem bark on serum lipid profile of STZ-induced diabetic rats VPX = Vitellaria paradoxa Each bar is a mean of five replicates ± S.E.M. Error bars with different superscripts are statistically different (p < 0.05).

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Abstract Background: Diabetes is considered the third leading cause of death around the globe with a projection increase of its prevalence by 2030. Aim: The study was aimed at investigating the anti-diabetic and safety properties of aqueous extract of Vitellaria paradoxa (VPX) stem bark in streptozotocin-induced diabetic rats. Materials and methods...

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Context 1
... this alteration was attenuated in all the extract treated groups in a dose dependent pattern and also compared favorably with the glibenclamide treated group (Table IV). Figure 1 shows the effect of aqueous extract of Vitellaria paradoxa stem bark on serum total cholesterol (TC), High density lipoprotein (HDL-c), low density lipoprotein (LDL-c) and triglyceride. The total cholesterol, low density lipoprotein and triglyceride significantly (p < 0.05) reduced upon the administration of the aqueous extract of Vitellaria paradoxa bark and glibenclamide when compared to the STZ-induced group. ...
Context 2
... all the diabetic treated groups expressed a significant (p < 0.05) up regulation in the activity of catalase when compared with the diabetic untreated group. Moreso, dose of 800 mg/kg of the extract did not show any significant difference (p < 0.05) in catalase level when compared to the group treated with the reference drug ( Figure 5). Figure 6 depict the level of lipid peroxidation in the pancreas of STZ-induced diabetic rats. ...
Context 3
... dose of 800 mg/kg of the extract did not show any significant difference (p < 0.05) in catalase level when compared to the group treated with the reference drug ( Figure 5). Figure 6 depict the level of lipid peroxidation in the pancreas of STZ-induced diabetic rats. A significant elevation (p < 0.05) was observed in malondialdehyde concentration in the pancreas of diabetic rats when compared with non-diabetic control. ...