Fig 5 - uploaded by Erij Messadi
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Effect of L2 on survival kinases in the ischemic myocardium. Protein phosphorylation was studied in sham operated hearts and in hearts subjected to 30 min regional ischemia followed by 20 min reperfusion and exposed to either vehicle (control), L2 (200 nM) or BNP (10 nM) perfusion. Data are presented as ratio of phosphorylated to total proteins and expressed relative to sham group values. Data are means ± SEM; AU: arbitrary unit; n = 4 per group. $, p<0.05, $ $, p<0.01 versus sham, *, p<0.05, **, p<0.01, ***, p<0.001 versus vehicle IR, †, p<0.05, † †, p<0.01, † † †, p<0.001 versus BNP.
Contexts in source publication
Context 1
... do that, phosphorylated PKCε/ ERK/GSK3β and PI3K/Akt/eNOS expression was determined by Western blotting. In our experiments, IR did not induce any modification in phosphorylated Akt and PKCε expression (Fig 5). However, they were increased after L2 perfusion [3.00-and 8.88-fold increase respectively (p<0.001) compared with vehicle; Fig 5]. ...
Context 2
... our experiments, IR did not induce any modification in phosphorylated Akt and PKCε expression (Fig 5). However, they were increased after L2 perfusion [3.00-and 8.88-fold increase respectively (p<0.001) compared with vehicle; Fig 5]. The amount of activated PI3K, ERK and GSK3β was increased after IR in the case of control hearts, while perfusion with L2 significantly enhanced the effect [pPI3K: 1.89-and pGSK3β: 1.92-fold increase (p<0.001) compared with vehicle; Fig 5], except for ERK where the increase was not significant. ...
Context 3
... they were increased after L2 perfusion [3.00-and 8.88-fold increase respectively (p<0.001) compared with vehicle; Fig 5]. The amount of activated PI3K, ERK and GSK3β was increased after IR in the case of control hearts, while perfusion with L2 significantly enhanced the effect [pPI3K: 1.89-and pGSK3β: 1.92-fold increase (p<0.001) compared with vehicle; Fig 5], except for ERK where the increase was not significant. IR decreased the amount of activated eNOS and this was reversed when hearts were perfused with L2 [1.77-fold increase (p<0.05) compared with vehicle; Fig 5]. ...
Context 4
... amount of activated PI3K, ERK and GSK3β was increased after IR in the case of control hearts, while perfusion with L2 significantly enhanced the effect [pPI3K: 1.89-and pGSK3β: 1.92-fold increase (p<0.001) compared with vehicle; Fig 5], except for ERK where the increase was not significant. IR decreased the amount of activated eNOS and this was reversed when hearts were perfused with L2 [1.77-fold increase (p<0.05) compared with vehicle; Fig 5]. ...
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