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Figure 3 - Flavonoid GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling

Figure 3. Effect of GL-V9 on CRC cell invasion and adhesion in vitro. (A-B) CRC cells HCT116 and SW480 treated with 10 μM and 20 μM GL-V9 for 24 h demonstrated significantly reduced migration and invasion through extracellular matrix as indicated by the transwell migration assay. Normal colon epithelial cells FHC with much lower invasive potential also showed reduced invasion through the extracellular matrix (ECM) after GL-V9 treatment, but with less reduction degree and statistical significance. The number of cells migrated through the ECM after 24 h was counted in five randomly selected (×200) microscopic fields. (C) GL-V9 treatment for 24 h at a concentration of 20 μM significantly reduced cell adhesion for both CRC cells HCT116 and SW480 and normal cells FHC, as indicated by cell attachment assay. Each error bar represents the mean ± S.D. of three replicate samples. * p<0.05; **, p<0.001.
Effect of GL-V9 on CRC cell invasion and adhesion in vitro. (A-B) CRC cells HCT116 and SW480 treated with 10 μM and 20 μM GL-V9 for 24 h demonstrated significantly reduced migration and invasion through extracellular matrix as indicated by the transwell migration assay. Normal colon epithelial cells FHC with much lower invasive potential also showed reduced invasion through the extracellular matrix (ECM) after GL-V9 treatment, but with less reduction degree and statistical significance. The number of cells migrated through the ECM after 24 h was counted in five randomly selected (×200) microscopic fields. (C) GL-V9 treatment for 24 h at a concentration of 20 μM significantly reduced cell adhesion for both CRC cells HCT116 and SW480 and normal cells FHC, as indicated by cell attachment assay. Each error bar represents the mean ± S.D. of three replicate samples. * p<0.05; **, p<0.001.
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