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Dynamic standardized incidence ratio of SHNC. (a) Year of EC diagnosis. (b) Age at EC diagnosis (years). (c) Latency after EC diagnosis (months). EC: esophageal cancer; NRT: no radiation therapy; RT: radiotherapy.

Dynamic standardized incidence ratio of SHNC. (a) Year of EC diagnosis. (b) Age at EC diagnosis (years). (c) Latency after EC diagnosis (months). EC: esophageal cancer; NRT: no radiation therapy; RT: radiotherapy.

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Background Impact of radiotherapy (RT) for esophageal cancer (EC) patients on the development of secondary head and neck cancer (SHNC) remains equivocal. The objective of this study was to investigate the link between definitive RT used for EC treatment and subsequent SHNC. Methods This study was conducted using the Surveillance, Epidemiology, and...

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Context 1
... the dynamic diagnosis year-SIR plot, there was a slightly increased risk of SHNC after RT in the years from 1980 to 1990, but there was an overall downward trend during the period of 1990 -2010 ( Fig. 5a). In the dynamic age-SIR plot, the risk of SHNC decreased as the age increases regardless of whether the RT group or the NRT group. The risk of SHNC in older EC patients (50 -74 years old) was less than the younger ones (20 -49 years old) in the RT group (Fig. 5b). The risk of developing SHNC exhibited a gradual increase, reaching its ...
Context 2
... to 1990, but there was an overall downward trend during the period of 1990 -2010 ( Fig. 5a). In the dynamic age-SIR plot, the risk of SHNC decreased as the age increases regardless of whether the RT group or the NRT group. The risk of SHNC in older EC patients (50 -74 years old) was less than the younger ones (20 -49 years old) in the RT group (Fig. 5b). The risk of developing SHNC exhibited a gradual increase, reaching its peak during late latency in the NRT group, as evident in the dynamic latency-SIR plot. Conversely, in the RT group, the risk of SHNC increased during early latency but decreased in the late latency period (Fig. ...
Context 3
... less than the younger ones (20 -49 years old) in the RT group (Fig. 5b). The risk of developing SHNC exhibited a gradual increase, reaching its peak during late latency in the NRT group, as evident in the dynamic latency-SIR plot. Conversely, in the RT group, the risk of SHNC increased during early latency but decreased in the late latency period (Fig. ...

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