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Drug-resistant mechanisms in mycobacteria. (1) The hydrophobic cell wall of mycobacteria "mycomembrane"; (2) Dormancy; (3) Target modification; (4) Modification of antibiotics; (5) Expression of efflux pumps.

Drug-resistant mechanisms in mycobacteria. (1) The hydrophobic cell wall of mycobacteria "mycomembrane"; (2) Dormancy; (3) Target modification; (4) Modification of antibiotics; (5) Expression of efflux pumps.

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Figure 1. Drug-resistant mechanisms in mycobacteria. (1) The...
Figure 2. Effect of efflux pumps on intracellular antibiotic...
Figure 5. Impact of efflux pump expression on drug resistance development.
Relevance of Efflux Pumps in the Development of Drug Resistance in Mycobacterial Infections
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  • Feb 2025
Mycobacteria, including nontuberculous mycobacteria (NTM) and Mycobacterium tuberculosis complex (MTB), are global pathogens of major concern due to their intrinsic drug resistance and their capacity to cause a wide range of severe infections. The treatment of mycobacterial infections is particularly challenging because of the multidrug resistance....
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... development of these mutations generates high levels of drug resistance [9]. In addition, the modification of antibiotics by mycobacteria results in the modified molecule not binding to its target (Figure 1) [7]. ...