Fig 6 - available via license: Creative Commons Attribution 4.0 International
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Diagnostic accuracy of the three tests under investigation based on Bayesian Latent Class Analysis in (a) S. haematobium and (b) S. mansoni endemic regions. CI conditional independence, CDP conditional dependence in positives, CDN conditional dependence in negatives, CDPN conditional dependence in positives and negatives, PCR polymerase chain reaction, POC-CCA point-of-care circulating cathodic antigen, UCP-LF-CAA up-converting reporter particle lateral flow circulating anodic antigen
Source publication
Background
Schistosoma haematobium and S. mansoni are endemic in Madagascar, but reliable diagnostic tools are often lacking, contributing to exacerbate transmission and morbidity. This study evaluated the diagnostic accuracy of three tests for schistosome infection in Malagasy adults from areas of medium to high endemicity.
Methods
This cross-sec...
Context in source publication
Context 1
... details on the pairwise and overall agreement are provided in Supplementary Table SI1.2 and SI1.3. Figure 6 presents Se and Sp estimates from five BLCM for the three diagnostic tests in S. haematobium and S. mansoni endemic areas [median values and 95% credible intervals (CrI)]. In both settings, PCR showed the highest sensitivity (95.2%, 95% CrI: 83.1-99.8 for S. haematobium; 95.7%, 95% CrI: 91.0-99.5 for S. mansoni) with narrow CrI, followed by UCP-LF CAA (87.8%, 95% CrI: 73.2-99.1) ...
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