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Diagnostic accuracy measures for the three index tests, against the reference standard of PCR on NPS
Source publication
Standard diagnosis of SARS-CoV-2 by nasopharyngeal swab (NPS) and real-time reverse transcriptase-polymerase chain reaction (PCR) requires a sophisticated laboratory, skilled staff, and expensive reagents that are difficult to establish and maintain in isolated, low-resource settings. In the remote setting of tropical Sumba Island, eastern Indonesi...
Contexts in source publication
Context 1
... an NPV of 77.6% (95% CI: 67.3-86.0) ( Table 2 and Supplemental Table 1). The median Ct values in positive NPS and FS specimens were similar, at 27.6 and 26.3 for E gene (P 5 0.583), and 31.8 and 30.7 for RdRp gene (P 5 0.564), respectively (Figures 3A and Supplemental Figure 2). ...Context 3
... of 68.3% (95% CI: 57.1-78.1) (Table 2 and Supplemental Table 1). LAMP sensitivities increased with higher viral loads for both NPS and FS specimens; for instance, 87.1% and 75% at Ct value , 26, and 73.0% and 70.2% at Ct value , 33, respectively ( Table 2). ...Context 4
... 2 and Supplemental Table 1). LAMP sensitivities increased with higher viral loads for both NPS and FS specimens; for instance, 87.1% and 75% at Ct value , 26, and 73.0% and 70.2% at Ct value , 33, respectively ( Table 2). ...Context 5
... for LAMP for up to 7 days of incubation, 25 DS became LAMP-negative over time (including nine on day 7, six on day 4, five on day 2, five on day 1); and 27 showed inconsistent positive or negative results over time (Table 4). LAMP results for all DS specimens are provided in Supplemental Table 2. ...Similar publications
Background: Since the external validation of severe acute respiratory syndrome coronavirus 2 antigen rapid diagnostic tests (SARS-CoV-2 RDT-Ags) is a necessary requisite before they can be introduced into routine clinical practice, this study reports the results of a real-world assessment of the clinical performance of the new COVID-VIRO ALL IN dev...
The pandemic of severe acute respiratory syndrome 2 (SARS-CoV-2) revealed the necessity of diagnosis of the infected people to prevent the prevalence infection cycle. Many commercial pathogen diagnosis methods are based on the detection of genomic materials. Isothermal amplification methods such as loop-mediated-isothermal amplification (LAMP) are...
