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Context 1
... and percentage of age, gender, educational status and occupational status of intervention and placebo group has been described in Table 1. (Table 2). ...
Context 2
... with diabetes was found in 50.9% in intervention group and 43.6% in the placebo group. Frequency and percentage of diabetes and co-morbidity, life style, diet, medication, test material and placebo material of intervention and placebo group has been described in Table 2. Anthropometric measurements: On paired sample T-test no significant change was found in intervention and placebo groups for height, weight and mid arm circumference, before and after intervention were seen. ...
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Citations
... Persimmon vinegar Acidity: 5.2% Reduced hepatic triglycerides and total cholesterol [124] Pineapple peel vinegar 0.8 ml vinegar High potency in restoring the Gonadosomatic Index on diabetic rats [125] Apple cider vinegar Different acidity and dilution Shows potential impact on glycemic control, hyperlipidemia and control on body weight in type 2 diabetes patients [126][127][128][129][130][131][132] Anti-hyperglycemic effect on postprandial glycemia in non-diabetic females [133] Rice vinegar -Acetic acid content reduced blood pressure and renin activity in spontaneously hypersensitive rat [134] Nypa palm vinegar -• Enhanced anti-glycemic effect compared to metformin. • Enhanced insulin level up to 79.8% • Significant anti-glycemic effect. ...
Agricultural residues and fruit/food wastes are a curse to the environment but this can also play an important role in meeting the growing needs for energy, value-added chemicals, and food security problems. Vinegar is an acidic liquid whose major component is acetic acid and consists of different organic acids and bioactive compounds. Vinegar is a substance produced by the acetic acid bacteria Acetobacter and Gluconobacter that has a 4% acetic acid content. For the efficient biological production of acetic acid, a variety of renewable substrates are used, including agro and food, dairy, and kitchen wastes. This reduces waste and lowers environmental pollution. There are different types of traditional vinegar available all over the world and have many applications. Vinegar can be made either naturally, through alcoholic and then acetic fermentation, or artificially, in laboratories. This chapter emphasizes the production and biotransformation of agricultural and fruit wastes into vinegar and the genetic manipulations done on microorganisms to utilize a wide range of substrates and achieve maximum product titer.
... The main characteristics of included clinical trials are provided in Table 2. Nine studies [4,12,16,20,22,23,27,28,33], comprising 686 total participants, with a mean age of 49.5 y, met the eligibility criteria and were selected for qualitative and quantitative analysis. These studies were published between 2008 and 2019, and had been conducted in Iran [4,12,22,27,28], USA [33], Japan [23], Pakistan [20], and Tunisia [16], respectively. ...
... The main characteristics of included clinical trials are provided in Table 2. Nine studies [4,12,16,20,22,23,27,28,33], comprising 686 total participants, with a mean age of 49.5 y, met the eligibility criteria and were selected for qualitative and quantitative analysis. These studies were published between 2008 and 2019, and had been conducted in Iran [4,12,22,27,28], USA [33], Japan [23], Pakistan [20], and Tunisia [16], respectively. Aside from one study [16], which did not report the gender of participants, all included studies had recruited both genders. ...
... Aside from one study [16], which did not report the gender of participants, all included studies had recruited both genders. Participants' clinical conditions were different across the included studies; where five trials had enrolled diabetic patients [12,16,20,27,28], 2 studies had included obese and/or overweight participants [22,23], one study had recruited type 2 diabetic patients with dyslipidemia [4], and one study did not report the condition of subjects [33]. All trials were of parallel design and the duration of intervention ranged between 30 and 90 days. ...
Background
Elevated lipid profiles and impaired glucose homeostasis are risk factors for several cardiovascular diseases (CVDs), which, subsequently, represent a leading cause of early mortality, worldwide. The aim of the current study was to conduct a systematic review and meta-analysis of the effect of apple cider vinegar (ACV) on lipid profiles and glycemic parameters in adults.
Methods
A systematic search was conducted in electronic databases, including Medline, Scopus, Cochrane Library, and Web of Knowledge, from database inception to January 2020. All clinical trials which investigated the effect of ACV on lipid profiles and glycemic indicators were included. Studies were excluded if ACV was used in combination with other interventions or when the duration of intervention was < 2 weeks. To account for between-study heterogeneity, we performed meta-analysis using a random-effects model.
Results
Overall, nine studies, including 10 study arms, were included in this meta-analysis. We found that ACV consumption significantly decreased serum total cholesterol (− 6.06 mg/dL; 95% CI: − 10.95, − 1.17; I²: 39%), fasting plasma glucose (− 7.97 mg/dL; 95% CI: − 13.74, − 2.21; I²: 75%), and HbA1C concentrations (− 0.50; 95% CI: − 0.90, − 0.09; I²: 91%). No significant effect of ACV consumption was found on serum LDL-C, HDL-C, fasting insulin concentrations, or HOMA-IR. The stratified analysis revealed a significant reduction of serum TC and TG in a subgroup of patients with type 2 diabetes, those who took ≤15 mL/day of ACV, and those who consumed ACV for > 8-weeks, respectively. Furthermore, ACV consumption significantly decreased FPG levels in a subgroup of studies that administered ACV for > 8-weeks. Further, ACV intake appeared to elicit an increase in FPG and HDL-C concentrations in apparently healthy participants.
Conclusion
We found a significant favorable effect of ACV consumption on FPG and blood lipid levels.
... Its antimicrobial properties are attributed to enzyme glucose oxidase which produces hydrogen per oxide on mixing the honey with water [11]. Vinegar is made from fermentable sugar source like dates, apple, grapes etc [12]. Studies have reported its bactericidal effects and biofilm removal properties that are beneficial for dental health. ...
Background: Salivary fluid creates a particular environment of oral cavity that helps in mastication, lubrication of food and mucosa and in speech. Intake of food and different liquids (drinks, juices, milk) causes modulation in pH of saliva that lead to change in the environment of oral cavity. The pH of saliva decreases to acidic side when bacteria breakdown the carbohydrates and start releasing acids, these acids damage the structure of tooth and leads to cavity formation i.e. dental caries. Objective: The current study is aimed to evaluate the salivary pH of diabetic and healthy individual before and after using honey and vinegar mouth rinses. Methods: It was a pre-clinical experimental study conducted in dental OPD of Baqai medical college Karachi from 1st January to 15th February. The calculated sample size N=80 was divided in 4 groups, Group A, n=20 healthy participants who rinsed with honey mouth rinse, Group B n=20 diabetics patients who rinsed with honey mouth rinse. Similarly, Group C, n=20 healthy participants who rinsed with vinegar mouth rinse and Group D, n=20 diabetic patients who rinsed with vinegar mouth rinse. 2 ml of saliva was collected by asking the participants to collect it in the floor of the mouth and swallowing for one minute was prohibited and after that they were asked to expectorate it into the sterile container. Then they were given the mouth rinse according to group distribution and after rinsing they were asked to wait for half an hour after that saliva was again collected from same participant to identify the rinse induced change in pH of oral cavity. Results: There was no any significant change in healthy participants of either group however in diabetic individuals significant change was observed by honey mouth rinse (p-value = 0.033) followed by vinegar mouth rinse (p-value = 0.043). Conclusion: Honey and vinegar mouth rinses are effective in maintaining the salivary pH in diabetic individuals.
... Diabetes mellitus (DM) is a significant public health issue that has been attributed to a change in lifestyle, decreased physical activity, and obesity. 1 Endocrine disorders cause impaired insulin secretion, hepatic glucose overproduction, and insulin resistance, which leads to the development of diabetes mellitus. 2 Co-morbidities such as dyslipidemia, atherosclerosis, and hypertension can all lead to complications. 3 By 2030, the World Health Organization (WHO) estimates that diabetes will be the seventh leading cause of death. 4 According to the International Diabetes Federation (IDF), there are approximately 382 million diabetics worldwide, with that figure projected to grow to 592 million by 2035. 2 Around 80% of people with diabetes live in low-income countries, and 60% of them are from Asia, with China accounting for one-third of the total. ...
The diabetes as a disease has been reported for 3500 years. Although diagnostic and therapeutic approaches have continuously developed, no definitive therapeutic approaches have so far been reached. Diabetes is not a single disease; it interferes with various systems in the body including nervous system and cardiovascular system. The therapeutic lines for type 1 diabetes start with insulin and will need another treatment such as metformin. On the other hand, type 2 diabetes treatment strategies start with metformin and there will be a need for another treatment, insulin according to the disease progression. At certain point, both types of diabetes are treated applying the same strategies. In this study, we followed another strategy by applying the use of apple cider vinegar in patient with type 1 diabetes, and patient with type 2 diabetes following getting each meal. The results showed that glucose levels were within reference range after five days. Taken together, the use of apple cider vinegar as a secondary treatment line with conventional diabetic treatment is promising and needs to be further investigated
... After having received from the author all other relevant standard deviation values, the corrected meta-analyses were calculated, which included data extracted form several others of the included studies. [6][7][8][9] The revised results do not differ substantially from the original results, apart from a reduction of the precision of the estimates, without changing statistical significance. However, one change worth noticing is that, in adults with diabetes, triglyceride level reduction becomes only marginally statistically significant, i.e., -7.86 mg/dL, 95% CI [-15.40, ...
Correspondence on ‘D.S. Valdes, D. So, P.A. Gill, N.J. Kellow, Effect of Dietary Acetic Acid Supplementation on Plasma Glucose, Lipid Profiles, and Body Mass Index in Human Adults: A Systematic Review and Meta-analysis., J. Acad. Nutr. Diet. (2021). https://doi.org/10.1016/j.jand.2020.12.002’
Note: The editor-in-chief forwarded my letter to the authors who will implement my suggestions in a corrigendum to the original article. To avoid redundancy, my letter will not be published, and instead credits to me will be included in the author’s corrigendum. The editor full email is reported at the end of the full document.
... From these, 16 studies involving 910 participants comprehensively met inclusion criteria and were included. [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] From the 60 excluded studies, the most common reasons for exclusion were investigation of wrong intervention or route of administration (ie, delivery of pure acetic acid in the absence of a food/ fluid matrix through intravenous injections or pill ingestion) (n ¼ 23) and postprandial data being solely analyzed after the intervention (n ¼ 15). All 16 included studies were eligible for quantitative assessment via meta-analysis. ...
... Of the defined subgroups specific for participant health status, two studies investigated healthy individuals (n ¼ 172), 43,44 four investigated overweight or obese participants who were otherwise healthy (n ¼ 245), 48,49,51,53 three 41,42,46 investigated individuals with metabolic conditions such as prediabetes, MetS, or hypercholesterolemia (n ¼ 111), and six recruited people with T2DM (n ¼ 342). 40,45,47,50,54,55 The health status of participants was not reported in one study (n ¼ 40) 52 ; however, as reported, TAG and LDL baseline data were within the healthy adult range (mean, 94 mg/dL and 111.2 mg/dL, respectively); it was analyzed within the healthy individuals' subgroup. The duration of included studies ranged from 1 to 12 weeks, with most interventions conducted using a parallel design (n ¼ 13). ...
... The habitual dietary intake of participants at baseline was assessed in 12 studies. [40][41][42][43][44][45]48,49,51,[53][54][55] Intervention adherence measurements and collection of dietary intake data during the intervention periods were assessed in nine trials. [42][43][44][45]48,49,51,53,55 A run-in period was included in five studies, lasting either 1, 51 2, 42,48,52 or 3 weeks. ...
Background
Acetic acid is a short-chain fatty acid that has demonstrated biomedical potential as a dietary therapeutic agent for the management of chronic and metabolic illness comorbidities. In human beings, its consumption may improve glucose regulation and insulin sensitivity in individuals with cardiometabolic conditions and type 2 diabetes mellitus. Published clinical trial evidence evaluating its sustained supplementation effects on metabolic outcomes is inconsistent.
Objective
This systematic review and meta-analysis summarized available evidence on potential therapeutic effects of dietary acetic acid supplementation via consumption of acetic acid–rich beverages and food sources on metabolic and anthropometric outcomes.
Methods
A systematic search was conducted in Medline, Scopus, EMBASE, CINAHL Plus, and Web of Science from database inception until October 2020. Randomized controlled trials conducted in adults evaluating the effect of dietary acetic acid supplementation for a minimum of 1 week were included. Meta-analyses were performed using a random-effects model on fasting blood glucose (FBG), triacylglycerol (TAG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), glycated hemoglobin (HbA1c), body mass index (BMI), and body fat percentage. Statistical heterogeneity was assessed by calculation of Q and I² statistics, and publication bias was assessed by calculation of Egger’s regression asymmetry and Begg’s test.
Results
Sixteen studies were included, involving 910 participants who consumed between 750 and 3600 mg acetic acid daily in interventions lasting an average of 8 weeks. Dietary acetic acid supplementation resulted in significant reductions in TAG concentrations in overweight and obese but otherwise healthy individuals (mean difference [MD] = −20.51 mg/dL [95% confidence intervals = −32.98, −8.04], P = .001) and people with type 2 diabetes (MD = −7.37 mg/dL [−10.15, −4.59], P < .001). Additionally, acetic acid supplementation significantly reduced FBG levels (MD = −35.73 mg/dL [−63.79, −7.67], P = .01) in subjects with type 2 diabetes compared with placebo and low-dose comparators. No other changes were seen for other metabolic or anthropometric outcomes assessed. Five of the 16 studies did not specify the dose of acetic acid delivered, and no studies measured blood acetate concentrations. Only one study controlled for background acetic acid-rich food consumption during intervention periods. Most studies had an unclear or high risk of bias.
Conclusion
Supplementation with dietary acetic acid is well tolerated, has no adverse side effects, and has clinical potential to reduce plasma TAG and FBG concentrations in individuals with type 2 diabetes, and to reduce TAG levels in people who are overweight or obese. No significant effects of dietary acetic acid consumption were seen on HbA1c, HDL, or anthropometric markers. High-quality, longer-term studies in larger cohorts are required to confirm whether dietary acetic acid can act as an adjuvant therapeutic agent in metabolic comorbidities management.
... This meta-analysis included six studies with a total of 317 participants conducted across five countries, including Iran (Mahmoodi et al., 2013), India (Nazni et al., 2015), the United States (White & Johnston, 2007), Pakistan (Ali et al., 2018;Kausar et al., 2019) and Korea (Yoon et al., 2012). All the studies were conducted between 2007 and 2019, with sample sizes ranging from 11 (White & Johnston, 2007) -55 (Kausar et al., 2019). ...
... This meta-analysis included six studies with a total of 317 participants conducted across five countries, including Iran (Mahmoodi et al., 2013), India (Nazni et al., 2015), the United States (White & Johnston, 2007), Pakistan (Ali et al., 2018;Kausar et al., 2019) and Korea (Yoon et al., 2012). All the studies were conducted between 2007 and 2019, with sample sizes ranging from 11 (White & Johnston, 2007) -55 (Kausar et al., 2019). Out of these studies, one study had a double-blind, placebo-controlled, quasi-experimental design (Mahmoodi et al., 2013), one study was a randomized crossover placebo-controlled trial (White & Johnston, 2007), and the remaining four studies were placebo-controlled randomized controlled trials (Ali et al., 2018;Kausar et al., 2019;Nazni et al., 2015;Yoon et al., 2012). ...
... All the studies were conducted between 2007 and 2019, with sample sizes ranging from 11 (White & Johnston, 2007) -55 (Kausar et al., 2019). Out of these studies, one study had a double-blind, placebo-controlled, quasi-experimental design (Mahmoodi et al., 2013), one study was a randomized crossover placebo-controlled trial (White & Johnston, 2007), and the remaining four studies were placebo-controlled randomized controlled trials (Ali et al., 2018;Kausar et al., 2019;Nazni et al., 2015;Yoon et al., 2012). The target populations in these studies were adult adults with type 2 diabetes mellitus. ...
Aim:
To systematically review the effectiveness of vinegar consumption in improving glycemic control in adults with type 2 diabetes mellitus.
Design:
A systematic review and meta-analysis.
Review sources:
The CINAHL, Excerpta Medica database (EMBASE), Medline, PubMed, Scopus and Cochrane databases were searched in April 2019. Interventional studies published in the English language, from inception to 15 April 2019, were included.
Review methods:
Two investigators independently assessed the quality of the studies, discussed their findings to reach consensus, and complied with the standards of the Cochrane. Handbook for Systematic Reviews of Interventions. Random-effects meta-analysis was conducted in Review Manager 5.3.5 to assess the effect size. A series of subgroup and sensitivity analyses were conducted to explore the causes of heterogeneity. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.
Results:
A total of 6 relevant studies, including 317 patients with type 2 diabetes mellitus, were selected from 356 studies identified through electronic searches and reference lists. The meta-analysis showed significantly better fasting blood glucose and hemoglobin A1c (HbA1c) level. In secondary analyses, there was a remarkable reduction in total cholesterol and low-density lipoprotein postintervention.
Conclusion:
Vinegar content varied across the studies, and the sample sizes in the included studies were relatively small. Therefore, caution should be exercised when trying to extrapolate the results to a larger population.
Impact:
Existing reviews are limited to narrative synthesis, lacking critical appraisal, heterogenous outcomes, nor any report of fasting blood glucose and HbA1c. This meta-analysis review extends the evidence on the beneficial effects of vinegar on glycemic control as measured by HbA1c and fasting blood glucose. Clinicians could incorporate vinegar consumption as part of their dietary advice for patients with diabetes.
... This meta-analysis included six studies with a total of 317 participants conducted across five countries, including Iran (Mahmoodi et al., 2013), India (Nazni et al., 2015), the United States (White & Johnston, 2007), Pakistan (Ali et al., 2018;Kausar et al., 2019) and Korea (Yoon et al., 2012). All the studies were conducted between 2007 and 2019, with sample sizes ranging from 11 (White & Johnston, 2007) -55 (Kausar et al., 2019). ...
... This meta-analysis included six studies with a total of 317 participants conducted across five countries, including Iran (Mahmoodi et al., 2013), India (Nazni et al., 2015), the United States (White & Johnston, 2007), Pakistan (Ali et al., 2018;Kausar et al., 2019) and Korea (Yoon et al., 2012). All the studies were conducted between 2007 and 2019, with sample sizes ranging from 11 (White & Johnston, 2007) -55 (Kausar et al., 2019). Out of these studies, one study had a double-blind, placebo-controlled, quasi-experimental design (Mahmoodi et al., 2013), one study was a randomized crossover placebo-controlled trial (White & Johnston, 2007), and the remaining four studies were placebo-controlled randomized controlled trials (Ali et al., 2018;Kausar et al., 2019;Nazni et al., 2015;Yoon et al., 2012). ...
... All the studies were conducted between 2007 and 2019, with sample sizes ranging from 11 (White & Johnston, 2007) -55 (Kausar et al., 2019). Out of these studies, one study had a double-blind, placebo-controlled, quasi-experimental design (Mahmoodi et al., 2013), one study was a randomized crossover placebo-controlled trial (White & Johnston, 2007), and the remaining four studies were placebo-controlled randomized controlled trials (Ali et al., 2018;Kausar et al., 2019;Nazni et al., 2015;Yoon et al., 2012). The target populations in these studies were adult adults with type 2 diabetes mellitus. ...
Background: There is a growing number of epidemiological evidences that suggest the effectiveness of vinegar consumption among adults with type 2 diabetes mellitus (T2DM). However, the current reviews are restricted on narrative synthesis, lack of critical appraisal, mixed population, heterogenous outcomes and fasting blood glucose and glycated hemoglobin A (HbA1c) not reported.
Objective: This systematic review and meta-analysis was conducted to evaluate the effectiveness of vinegar consumption on glycemic control in adults with T2DM.
Methods: Six electronic databases research studies published in the English language from inception to 15 April 2019 was undertaken and reviewed. This includes: CINAHL, EMBASE, Medline, PubMed, Scopus and Cochrane. Random-effects meta-analysis was adopted to assess effect size, calculated using standardized mean difference and 95% confidence interval. Funnel plots and the Egger’s test were used to assess publication bias.
Results: A total of 6 relevant studies, that included 378 adults with diabetes mellitus, were selected from 356 studies identified through electronic searches and reference lists. The meta-analysis shows a significantly improvement in the fasting blood glucose (combined MD = 0.78, 95% CI: -1.21 to -0.36, p < 0.001), HbA1c (combined MD = 1.77, 95% CI: -3.02 to -0.52, p = 0.005) and change in HbA1c (combined MD = 0.36, 95% CI: -1.61 to -0.12, p = 0.004). On secondary analysis, there was a remarkable reduction on total cholesterol (combined MD = 13.82, 95% CI: -22.56 to -5.08, p = 0.002) and low-density lipoprotein (combined MD = 10.36, 95% CI: -19.07 to -1.64, p = 0.02) at post-intervention.
Conclusions: Clinicians may incorporate vinegar consumption, as part of their dietary advices for adults with diabetes, to facilitate the design of an effective diabetes self-management program in the clinical setting. However, cautions need to be exercised when trying to extrapolate the result to a larger population due to relatively small sample size in included studies
... This meta-analysis included six studies with a total of 317 participants conducted across five countries, including Iran (Mahmoodi et al., 2013), India (Nazni et al., 2015), the United States (White & Johnston, 2007), Pakistan (Ali et al., 2018;Kausar et al., 2019) and Korea (Yoon et al., 2012). All the studies were conducted between 2007 and 2019, with sample sizes ranging from 11 (White & Johnston, 2007) -55 (Kausar et al., 2019). ...
... This meta-analysis included six studies with a total of 317 participants conducted across five countries, including Iran (Mahmoodi et al., 2013), India (Nazni et al., 2015), the United States (White & Johnston, 2007), Pakistan (Ali et al., 2018;Kausar et al., 2019) and Korea (Yoon et al., 2012). All the studies were conducted between 2007 and 2019, with sample sizes ranging from 11 (White & Johnston, 2007) -55 (Kausar et al., 2019). Out of these studies, one study had a double-blind, placebo-controlled, quasi-experimental design (Mahmoodi et al., 2013), one study was a randomized crossover placebo-controlled trial (White & Johnston, 2007), and the remaining four studies were placebo-controlled randomized controlled trials (Ali et al., 2018;Kausar et al., 2019;Nazni et al., 2015;Yoon et al., 2012). ...
... All the studies were conducted between 2007 and 2019, with sample sizes ranging from 11 (White & Johnston, 2007) -55 (Kausar et al., 2019). Out of these studies, one study had a double-blind, placebo-controlled, quasi-experimental design (Mahmoodi et al., 2013), one study was a randomized crossover placebo-controlled trial (White & Johnston, 2007), and the remaining four studies were placebo-controlled randomized controlled trials (Ali et al., 2018;Kausar et al., 2019;Nazni et al., 2015;Yoon et al., 2012). The target populations in these studies were adult adults with type 2 diabetes mellitus. ...
Apples are affordable and accessible fruit with tremendous biodiversity. Among over 10,000 identified apple cultivars, only a few are commercially available. Habitual fruit consumption is correlated with the prevention of Type 2 diabetes and related complications. Particularly, (poly)phenols found in apples are major contributors to their antidiabetic properties. Here, we have screened (poly)phenol‐rich extracts of 476 apple accessions in Canada's Apple Biodiversity Collection for antidiabetic properties. The results of this work provide insights into the prevention and management of Type 2 diabetes by identifying high (poly)phenol‐containing specialty apples for use in fresh fruit form or value‐added functional food ingredients. The recent trend in sedentary lifestyles and nutritionally‐imbalanced diets has elevated the prevalence of Type 2 diabetes in many parts of the world. Some pharmacological glycemic management can cause undesirable gastrointestinal side effects or hypoglycemia. Thus, there is a growing interest in safe glycemic management using dietary (poly)phenols. In this study, (poly)phenol‐rich extracts of 476 apple accessions from Canada's Apple Biodiversity Collection (ABC) and six major apple (poly)phenols were assessed for in vitro antidiabetic properties against the activities of α‐glucosidase, α‐amylase, and dipeptidyl peptidase‐4 (DPP‐4) and the formation of advanced glycation end products (AGE). Apple (poly)phenol extracts varied in their antidiabetic activities in a dose‐dependent manner. High (poly)phenol‐containing apples demonstrated that their total phenolic contents (TPC) were inversely correlated with the IC50 values of α‐glucosidase, α‐amylase, and AGE formation, but not DPP‐4. Concentrations of major (poly)phenol compounds such as procyanidin B2, phloridzin, and epicatechin in apples were significantly inversely correlated with IC50 values of α‐glucosidase in the high (poly)phenol‐containing apples. High TPC apples are not suitable for marketing for fresh fruit consumption due to bitterness and astringency; however, these apples show potential to use in the development of value‐added functional food ingredients or nutraceuticals for blood glucose management. The high TPC apple, “S23‐03‐749,” an advanced breeding line of dessert apple, presents a novel option as a specialty apple cultivar for the dietary management of glycemia. Les pommes sont des fruits abordables et accessibles avec une formidable biodiversité. Parmi plus de 10,000 cultivars de pommiers identifiés, seuls quelques‐uns sont disponibles dans le commerce. La consommation habituelle de fruits est corrélée à la prévention du diabète de type 2 et des complications associées. En particulier, les (poly)phénols présents dans les pommes sont des contributeurs majeurs à leurs propriétés antidiabétiques. Ici, nous avons examiné des extraits riches en (poly)phénols de 476 pommes de la Collection Biodiversité des pommes du Canada pour leurs propriétés antidiabétiques. Les résultats de ces travaux donnent un aperçu de la prévention et de la gestion du diabète de type 2 en identifiant des pommes de spécialité à haute teneur en (poly)phénols à utiliser sous forme de fruits frais ou d'ingrédients alimentaires fonctionnels à valeur ajoutée. Apples are affordable and accessible fruit with tremendous biodiversity. Among over 10,000 identified apple cultivars, only a few are commercially available. Habitual fruit consumption is correlated with the prevention of Type 2 diabetes and related complications. Particularly, (poly)phenols found in apples are major contributors to their antidiabetic properties. Here, we have screened (poly)phenol‐rich extracts of 476 apple accessions in Canada's Apple Biodiversity Collection for antidiabetic properties. The results of this work provide insights into the prevention and management of Type 2 diabetes by identifying high (poly)phenol‐containing specialty apples for use in fresh fruit form or value‐added functional food ingredients.
