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Design of the BACOP schedule. 

Design of the BACOP schedule. 

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At present we report the results of a prospective, non-randomized open trial, conducted on follicular lymphoma (FL) patients by the Gruppo Italiano per lo Studio dei Linfomi (GISL), after a median follow-up of 62.6 months. Seventy-three patients with FL were registered to the study and treated with combination chemotherapy consisting of cyclophosph...

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... to the original schedule, in our study doxorubicin 25 mg/m 2 was substituted by epidoxorubicin 30 mg/m 2 . Briefly, treatment consisted, as reported in Fig. 1, of vincristine 1.4 mg/m 2 (cap 2 mg), cyclophos- phamide 650 mg/m 2 , epidoxorubicin 30 mg/m 2 , all given intravenously on days 1 and 8; bleomycin 5 mg/m 2 given intravenously on days 15 and 22; and prednisone 60 mg/m 2 given orally on days 15 -28. Treatments were repeated every 4 weeks on an out patient basis. Dose reductions or ...

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... The inclusion criteria and statistical method used are reported in the original papers. 15,16 Among 625 indolent lymphomas enrolled in several clinical trials, [17][18][19][20][21][22][23] we identified a total of 563 patients who met all inclusion criteria. In the second study, 1280 patients among 1387 cases with DLBCL were selected and evaluated for secondary neoplasm. ...
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