Figure 1 - uploaded by Samuel Veres
Content may be subject to copyright.
DSC (A) and HIT (B & C) analyses of bovine fetal CDE and SDF tendons. Data for adult tendons are also shown.  

DSC (A) and HIT (B & C) analyses of bovine fetal CDE and SDF tendons. Data for adult tendons are also shown.  

Source publication
Conference Paper
Full-text available
Positional tendons and energy-storing tendons from the forelimbs of quadrupeds are an excellent model to assess mechanical/mechanopathological differences between two functionally distinct classes of ten- dons. The common digital extensor (CDE, positional) and superficial digital flexor (SDF, energy-storing) are ana- tomically proximate, but experi...

Contexts in source publication

Context 1
... in fetal life, adjacent flexor and extensor tendons are markedly different. DSC endo- therm onset and peak temperatures were lower for SDF tendons compared to matching CDE tendons: that is, the energy-storing tendons had collagen which was less thermally stable (Fig. 1A). This may indicate greater collagen turnover. In direct contrast, HIT (which assesses mechanically functional crosslinking) showed that fetal SDF tendons had higher denaturation temperatures (Fig. 1B). Therefore, the collagen in the energy-storing tendons was more resistant to water solvation, perhaps due to greater crosslink-induced ...
Context 2
... were lower for SDF tendons compared to matching CDE tendons: that is, the energy-storing tendons had collagen which was less thermally stable (Fig. 1A). This may indicate greater collagen turnover. In direct contrast, HIT (which assesses mechanically functional crosslinking) showed that fetal SDF tendons had higher denaturation temperatures (Fig. 1B). Therefore, the collagen in the energy-storing tendons was more resistant to water solvation, perhaps due to greater crosslink-induced molecular packing. There was a posi- tive linear correlation between denaturation temperature and fetal age for the energy-storing SDF tendons (p=0.003, R 2 =0.79), but not for positional CDE tendons. ...
Context 3
... due to greater crosslink-induced molecular packing. There was a posi- tive linear correlation between denaturation temperature and fetal age for the energy-storing SDF tendons (p=0.003, R 2 =0.79), but not for positional CDE tendons. Under HIT, the fetal SDF tendons also sustained load under much higher temperatures than could the CDE tendons (Fig. 1C). Both of these results indicate that func- tional crosslinking forms more completely in SDF tendons during fetal development. Thus, even before gait be- gins, energy-storing and positional tendons diverge structurally-as seen in adults (Fig. 1A-C). Conclusions: Our results clearly demonstrate that different collagen structures form ...
Context 4
... the fetal SDF tendons also sustained load under much higher temperatures than could the CDE tendons (Fig. 1C). Both of these results indicate that func- tional crosslinking forms more completely in SDF tendons during fetal development. Thus, even before gait be- gins, energy-storing and positional tendons diverge structurally-as seen in adults (Fig. 1A-C). Conclusions: Our results clearly demonstrate that different collagen structures form within bovine positional (CDE) and energy-storing (SDF) tendons during fetal development, in the absence of differences in functional mechanical loading. The structural and mechanical differences that exist between functionally distinct adult ten- ...

Citations

Article
Full-text available
Statement of significance: Collagen fibrils-nanoscale biological cables-are the fundamental load-bearing elements of all structural human tissues. While all collagen fibrils share common features, such as being composed of a precise quarter-staggered polymeric arrangement of triple-helical collagen molecules, their structure can vary significantly between tissue types, and even between different anatomical structures of the same tissue type. To understand normal function, homeostasis, and disease of collagenous tissues requires detailed knowledge of collagen fibril structure-function. Using anatomically proximate but structurally distinct tendons, we show that collagen fibrils in functionally distinct tendons have differing susceptibilities to damage under both tensile overload and cyclic fatigue loading. Our results suggest that the structure of collagen fibrils may lead to a strength versus fatigue resistance tradeoff, where high strength is gained at the expense of fatigue resistance, and vice versa.