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The manifestation of COVID-19 severity and mortality has been associated with dysregulation of the immune response, often influenced by racial disparities and conferred by changes in hematological and immunological parameters. The biological and hematological parameters as well as the cytokine profiles have been investigated in a cohort of 61 COVID...
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Context 1
... < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. revealed an upward trend in the IL-4 and IL-6 levels and, interestingly, a downward trend in the IFN-g levels from the mild to severe groups of patients with COVID-19 (Table 3). The severe group manifested significantly higher IL-4 levels (p < 0.001) than its mild counterpart, whereas the moderate and severe groups manifested significantly higher IL-6 levels (p < 0.05 and p < 0.001, respectively) than the mild group Figure 3A, B). ...Context 2
... < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. revealed an upward trend in the IL-4 and IL-6 levels and, interestingly, a downward trend in the IFN-g levels from the mild to severe groups of patients with COVID-19 (Table 3). The severe group manifested significantly higher IL-4 levels (p < 0.001) than its mild counterpart, whereas the moderate and severe groups manifested significantly higher IL-6 levels (p < 0.05 and p < 0.001, respectively) than the mild group Figure 3A, B). ...Citations
... COVID-19 severity and mortality are known to be associated with specific changes in hematological characteristics and immunity. ESR and other hematological parameters were shown to be significantly increased in a cohort of 61 COVID-19-positive patients from Bangladesh [24]. A higher acute systemic inflammatory response was shown to be associated with a larger decrease in blood hemoglobin levels in a 55-year-old male patient admitted for a period of 28 days. ...
Background:
The manifestations, severity, and mortality of COVID-19 are considered to be associated with the changes in various hematological parameters and in immunity. Associations of immunoglobulin G antibodies against severe acute respiratory syndrome-linked coronavirus (IgG-SARS)-positive status with cardiac function and hematological and biochemical parameters in apparently health subjects are poorly understood.
Methods:
The present cross-sectional study included 307 healthy volunteers (24-69 years of age; 44.8 ± 8.6 years; 80.4% men) and was initiated in 2019 before the COVID-19 pandemic. COVID-19 episodes were confirmed by detection of IgG-SARS against SARS-CoV-2 S1 RBD to reveal 70 IgG-SARS-positive and 237 negative participants. Numerous ultrasound characteristics were assessed by echocardiography, and 15 hematological and biochemical parameters were assayed in the blood. Descriptive and comparative analysis was based on the IgG-SARS status of the participants.
Results:
The left ventricular mass index, mitral ratio of peak early to late diastolic filling velocity or flow velocity across the mitral valve, and deceleration time of early mitral inflow were decreased (p < 0.05) in IgG-SARS-positive participants versus those in IgG-SARS-negative participants according to multivariate logistic regression analysis. Erythrocyte sedimentation rate and platelet count were slightly increased, and blood hemoglobin was decreased in IgG-SARS-positive participants compared with those in IgG-SARS-negative participants.
Conclusions:
LV filling, inflammation, blood coagulation, and hemoglobin appear to be influenced by COVID-19 infection in healthy participants. Our observations contribute to the definition of vulnerabilities in the apparently healthy subjects with long COVID-19. These vulnerabilities may be more severe in patients with certain chronic diseases.
... COVID-19 severity and mortality are known to be associated with specific changes in hematological characteristics and immunity. ESR and other hematological parameters were shown to be significantly increased in a cohort of 61 COVID-19-positive patients from Bangladesh [22]. A higher acute systemic inflammatory response was shown to be associated with a larger decrease in blood hemoglobin levels in a 55-year-old male patient admitted for a period of 28 days. ...
Background: The manifestations, severity, and mortality of COVID-19 are considered to be associated with the changes in various hematological parameters and in immunity. Associations of immunoglobulin G antibodies against severe acute respiratory syndrome-linked coronavirus (IgG-SARS)-positive status with cardiac function and hematological and biochemical parameters in apparently health subjects are poorly understood. Methods: The present cross-sectional study included 307 healthy volunteers (24-69 years of age; 44.8±8.6 years; 80.4% men) and was initiated in 2019 before the COVID-19 pandemic. COVID-19 episodes were confirmed by detection of IgG-SARS against SARS-CoV-2 S1 RBD to reveal 70 IgG-SARS-positive and 237 negative participants. Numerous ultrasound characteristics were assessed by echocardiography, and 15 hematological and biochemical parameters were assayed in the blood. Descriptive and comparative analysis was based on the IgG-SARS status of the participants. Results: The left ventricular mass index, mitral ratio of peak early to late diastolic filling velocity or flow velocity across the mitral valve, and deceleration time of early mitral inflow were decreased (P<0.05) in IgG-SARS-positive participants versus those in IgG-SARS-negative participants according to multivariate logistic regression analysis. Erythrocyte sedimentation rate and platelet count were slightly increased, and blood hemoglobin was decreased in IgG-SARS-positive participants compared with those in IgG-SARS-negative participants. Conclusions: LV filling, inflammation, blood coagulation, and hemoglobin appear to be influenced by COVID-19 infection in healthy participants. These observations contribute to the development of a population recovery strategy after the episodes of COVID-19.
