Figure 3 - uploaded by Mónica Suárez Korsnes
Content may be subject to copyright.
Cumulative distributions for time from start of exposure to first cell division for control and exposed cells (derived from individual cell tracking). Note that exposed cells tend to divide at least as frequent as control cells up to about eight hours from start of exposure. This result illustrates potential methods for early detection of premature cell division based on more extensive cell tracking as demonstrated in the present work.
Source publication
An intention for this work is to lay out a case study to explore individual cell tracking as a tool in toxicological research. Individual cell tracking is a developing technology which can potentially provide fast diagnosis of changes in cell populations for example due to toxic insults. It can also help to guide hypothesis formulation in pilot stu...
Context in source publication
Context 1
... study shows results from exposing BC3H1 cells to 100 nM YTX where they due to a spatially sparse distribution have minor contact inhibition of proliferation (Fig1). Individual cell tracking indicates that YTX exposure then seems to lock the cells into an anti-proliferative state after their first division (Figs 2,3) leading to the hypothesis that YTX can be genotoxic. Additional biochemical analyses as well as morphological inspections evidence that YTX treatment induces a permanent mitotic failure leading to mitotic catastrophe. ...
