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Correlation between age-adjusted obesity deaths and glyphosate applications and percentage of US corn and soy crops that are GE.
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A huge increase in the incidence and prevalence of chronic diseases has been reported in the United
States (US) over the last 20 years. Similar increases have been seen globally. The herbicide
glyphosate was introduced in 1974 and its use is accelerating with the advent of herbicide-tolerant
genetically engineered (GE) crops. Evidence is mounting t...
Context in source publication
Context 1
... to Samsel & Seneff (2013b), glyphosate also disrupts the gut microbial balance. Data for inflammatory bowel disease were obtained from the CDC hospital discharge data and are plotted in Figure 20 (CDC, 2013e). Data for deaths due to intestinal infection were obtained from the CDC mortality files (CDC, 2013b) and are shown in Figure 21. ...Citations
... It is immobilized and bound to soil particles; however, glyphosate and phosphate have similar binding sites in soil; therefore, the application of phosphate fertilizers to plants or soil can desorb residual soil glyphosate to create extensive damage to crop production and decrease crop and environmental quality (Bott et al. 2011;Gomes et al. 2015). Direct and indirect (chronic) health effects of agricultural chemicals, especially glyphosate, on humans, animals, and the environment are of great concern (Mason 2013; Swanson et al. 2014;Van Bruggen et al. 2018;Wilson and Huber 2021). Because of these interactions, it is important to degrade residual soil glyphosate rather than just immobilizing it in soil by binding to soil particles and through chelation that also immobilizes plant essential mineral elements. ...
The creation of undesirable (soggy) sauerkraut resulted in the loss of $1,000,000 worth of organic sauerkraut in 2022, which prompted a multistep investigation of the cause and potential solution. The cause of this condition has been previously reported as unique fermentation conditions and the lack of key trace nutrients essential for cabbage ( Brassica oleracea var. capitata ) cell wall integrity. Because the condition was limited to organic sauerkraut in 2022, this investigation initially focused on differences in fermentation conditions between organic and conventional sauerkraut. No differences in fermentation conditions accounted for the condition; therefore, attention was focused on analyzing the mineral content of cabbage grown for sauerkraut production that pinpointed a deficiency in critical micronutrients such as iron, copper, manganese, boron, and zinc. This deficiency was traced to the use of poultry manure that was contaminated with glyphosate residue from conventionally fed turkeys and chickens that consumed genetically engineered (GE) feed and used as the fertilizer for organic cabbage production. The presence of glyphosate, a potent mineral chelator and antibiotic, was identified as a significant factor that impairs the absorption and physiological function of essential minerals in the shikimate metabolic pathway whereby cell walls and lignin are produced, thus compromising the structural quality of the sauerkraut. After this discovery, the study progressed to evaluate various remediation strategies aimed at eliminating glyphosate from the soil and restoring nutrient uptake. Corn grain and silage were selected as the test crops for this phase. Among the tested remediation solutions were raw sauerkraut juice containing Lactobacillus plantarum , which is reported to degrade glyphosate in the rumen of dairy cows and two patented proprietary microbial mixtures, PB027 and PB027SK, that degrade glyphosate by all three of the known metabolic pathways. These treatments were specifically formulated to degrade residual glyphosate in the soil. The results showed that these interventions could reduce soil glyphosate levels by 80% to 90% within 6 to 7 months to significantly enhance both the yield and quality of corn grain and silage. The increase in corn grain yield from glyphosate degradation on the Shiocton silt loam soil was 907.89 kg·ha ⁻¹ (13.5 bushels/acre). The increase in yield on the irrigated Kidder sandy loam soil was quantified at 726.31 kg·ha ⁻¹ (10.8 bushels/acre) for corn grain and 6.62 t·ha ⁻¹ (2.68 t/acre) for silage, with an additional improvement in silage feed quality beneficial for milk production. The findings underscore the importance of addressing both micronutrient sufficiency and glyphosate residue in soil to ensure the optimal growth of cabbage and the quality of sauerkraut produced. By successfully identifying manure as a subtle source of nutrient immobilization and implementing effective soil remediation techniques, this research highlights a clear path forward for improving crop yield and quality to ultimately enhance the structural integrity and consumer acceptance of sauerkraut. This study has broader applications for the nutritional content and crop yields of many organic crops that use conventional poultry and animal manures that may contain glyphosate in desiccated plant tissues or GE feeding operations.
... Existe evidencia suficiente de los límites sociales del agronegocio sojero ya que está comprobada su incidencia en el aumento notable de afecciones neurológicas, así como sus efectos teratogénicos y cancerígenos. A pesar de los registros insuficientes, el Paraguay presenta altas y crecientes tasas de mortalidad por cáncer, así como preocupantes tasas de crecimiento de la mortalidad infantil por deformaciones que escalan de año en año, de la mortandad infantil por deformaciones (Swanson et al, 2014;Seneff et al, 2015;Mesnage, 2014;Bellinger et al, 2016;Fogel, 2018). ...
En el trabajo se analizan las modalidades e impactos de la expansión del capital agrario en el Paraguay, respondiendo a la movilidad del mercado global de capitales. Esas formas de intervención están asociadas al extractivismo agrario que operan como economías de enclave; éstas al basarse en la explotación desregulada de recursos naturales responden a ciclos de constitución, expansión y decadencia. La caracterización de las formas de extractivismo que se dieron y se siguen desarrollando permite un análisis comparativo de sus impactos. Las conclusiones destacan los costos sociales y ambientales del capital agrario orientado al extractivismo, con escasos vínculos con el mercado interno, y tiene implicancias para las políticas públicas y para el debate sobre el desarrollo. En el artículo se explotan datos secundarios de tipo estadístico, resultados de investigaciones publicadas y entrevistas semiestructuradas.
... Several synthetically produced amino acids, close structural analogues of natural amino acids, can be erroneously incorporated into peptides [22,23]. The correlations between glyphosate use and the recent alarming rise in several modern diseases are striking, as presented by Swanson et al. [24] These include obesity, diabetes, end-stage renal disease, kidney failure, autism, Alzheimer's disease, dementia, Parkinson's disease, multiple sclerosis, intestinal infection, inflammatory bowel disease, stroke, leukemia, thyroid cancer, liver cancer, pancreatic cancer and kidney cancer [24] . ...
... Several synthetically produced amino acids, close structural analogues of natural amino acids, can be erroneously incorporated into peptides [22,23]. The correlations between glyphosate use and the recent alarming rise in several modern diseases are striking, as presented by Swanson et al. [24] These include obesity, diabetes, end-stage renal disease, kidney failure, autism, Alzheimer's disease, dementia, Parkinson's disease, multiple sclerosis, intestinal infection, inflammatory bowel disease, stroke, leukemia, thyroid cancer, liver cancer, pancreatic cancer and kidney cancer [24] . ...
... In this study, correlations were found between the use of pesticides and spontaneous abortions in group "B" of CYP2C9 genotypes (intermediate metabolizers). Swanson et al. [24] showed that the endocrine disrupting properties of glyphosate can lead to reproductive problems, such as infertility, miscarriage, birth defects and changes in sexual development. Glyphosate has also been linked to polycystic ovary syndrome, a major factor in female infertility, through its estrogenic properties [64]. ...
Brazil is the world leader in pesticide consumption, and its indiscriminate use puts farmers’ health at risk. The CYP2C9 gene stands out for encoding the CYP2C9 enzyme, which metabolizes several endogenous substrates and specific xenobiotics, especially pesticides. Our goal is to study the risk of pesticide use, espe-cially the herbicide glyphosate, in the development of diseases and the association with two CYP2C9 poly-morphisms, in farmers living in the southern region of Espírito Santo state, Brazil. The allelic frequency of CYP2C9*1, CYP2C9*2 and CYP2C9*3 was determined in blood samples from individuals exposed or not to pesticides using real-time PCR. 304 blood samples were analyzed, dividing CYP2C9 genotypes into three metabolization classes: normal, intermediate, and slow. Our results show that normal metabolizers are more vulnerable to diseases such as blood pressure changes and cardiovascular and kidney problems, while in-termediate metabolizers show an association with attention deficit disorder and miscarriages, suggesting that farmers in the studied region developed symptoms correlated to the CYP2C9 genotype they have. This work is pioneering in associating specific genetic variations and health risks with pesticide exposure, em-phasizing the importance of personalized medicine and stricter regulation of pesticide use for public health and occupational safety.
... Due to their simultaneous exposure in the cultivation of genetically modified soybeans, worries have been raised concerning the potential synergistic estrogenic effects of glyphosate and the phytoestrogen "genistein," a prevalent isoflavone present in soybeans and products made from them [13]. Glyphosate has been shown to have endocrine-disrupting properties [13], [14], can have an impact on human erythrocytes in vitro [15], and can increase the carcinogenicity of mice's skin [16]. Additionally, the shikimate pathway, which is found in bacteria, plants, and human gut microorganisms, is thought to be severely disrupted by it. ...
... A recent investigation looked into the potential link between glyphosate, genetically modified foods, and declining health in the USA. Concerns concerning potential links between glyphosate use and a variety of health issues and diseases, including cancer, hypertension, diabetes, strokes, autistic disorder, kidney failure, and Parkinson's and Alzheimer's disease, were highlighted by correlation analyses [14]. Additionally, there are concerns that glyphosate may contribute to gluten sensitivity, which has been related to a deficiency in crucial trace metals, issues during pregnancy, and an increased risk of developing non-Hodgkin's lymphoma [19]. ...
... Herbicide use increased more than tenfold (from 35 to 478 million pounds) as more U.S. farmers began to treat their fields with these chemicals" (Fernandez-Cornejo et al., 2014, p. 11). The increase in herbicides and pesticides is correlated with a significant deterioration of health in the United States (Swanson et al., 2014), as illustrated in the following figures reproduced with permission. ...
... Correlation between age-adjusted diabetes prevalence and glyphosate applications and percentage of US corn and soy crops that are GE. Reproduced from Swanson et al. (2014). ...
... Correlation between children with autism and glyphosate applications. Reproduced from Swanson et al. (2014). ...
Mental health symptoms of attention deficit hyperactivity disorder (ADHD), Autism, anxiety and depression have increased over the last 15 years. An additional risk factor that may affect mental and physical health is the foods we eat. Even though, our food may look and even taste the same as compared to 50 years ago, it contains herbicide and pesticide residues and often consist of ultra-processed foods. These foods (low in fiber, and high in sugar, animal fats and additives) are a significant part of the American diet and correlate with higher levels of inattention and hyperactivity in children with ADHD. Due to affluent malnutrition, many children are deficient in essential vitamins and minerals. We recommend that before beginning neurofeedback and behavioral treatments, diet and lifestyle are assessed (we call this Grandmother therapy assessment). If the diet appears low in organic foods and vegetable, high in ultra-processed foods and drinks, then nutritional deficiencies should be assessed. Then the next intervention step is to reduce the nutritional deficiencies and implement diet changes from ultra-processed foods to organic whole foods. Meta-analysis demonstrates that providing supplements such as Vitamin D, etc. and reducing simple carbohydrates and sugars and eating more vegetables, fruits and healthy fats during regular meals can ameliorate the symptoms and promote health.
... 156 We note that exposure to the herbicide glyphosate (Roundup®) may be linked to MAP-associated human disease 157 owing to glyphosate's ability to kill commensal but not pathogenic bacteria. [158][159][160] However, we are not aware on any studies showing decreased CM risk with herbicides killing pathogenic bacteria. ...
Infectious etiologies have previously been proposed as causes of both melanoma and non‐melanoma skin cancer. This exploratory overview explains and presents the evidence for the hypothesis that a microorganism excreted in infected ruminant animal feces, Mycobacterium avium subspecies paratuberculosis (MAP), is the cause of some cases of cutaneous melanoma (CM). Occupational, residential, and recreational contact with MAP‐contaminated feces, soil, sand, and natural bodies of water may confer a higher rate of CM. Included in our hypothesis are possible reasons for the differing rates and locations of CM in persons with white versus nonwhite skin, why CM develops underneath nails and in vulvar skin, why canine melanoma is an excellent model for human melanoma, and why the Bacille Calmette‐Guérin (BCG) vaccine has demonstrated efficacy in the prevention and treatment of CM. The pathogenic mechanisms and etiologic aspects of MAP, as a transmittable agent underlying CM risk, are carefully deliberated in this paper. Imbalances in gut and skin bacteria, genetic risk factors, and vaccine prevention/therapy are also discussed, while acknowledging that the evidence for a causal association between MAP exposure and CM remains circumstantial.
... Agricultural chemicals have been found to alter gut microbiota, which according to various authors, could be an important mediating factor between environment and health (Giambò, Teodoro, Costa, & Fenga, 2021;Shehata et al., 2013). On this matter, Swanson, Leu, & Abrahamson's (2014) found a strong positive correlation between the rise in glyphosate usage and the rise in IBD over time. ...
Inflammatory bowel disorders (IBD) are considered to be caused by autoimmunity. Available drug treatments only treat symptoms, and they typically work by suppressing the immune system. In this paper we retrospectively analyse the evolution of eight IBD patients who followed the GAPS Nutritional Protocol, a dietary treatment focused on normalising the gut flora and healing the gut wall. Data were quantitative (faecal calprotectin with a structured questionnaire) and qualitative (interviews together with the open-ended section of the questionnaire). Faecal calprotectin was normalised in seven participants (87.5%). IBD-related symptoms improved in all participants, and disappeared completely in five (62.5%). All participants discontinued their mainstream medications. The GAPS Nutritional Protocol had a dramatic positive impact on comorbidities-eczema, anxiety, depression, obsessive-compulsive disorder, arthritis and adrenal fatigue, with clear improvements in quality of life. In this paper, we put forward a hypothesis that autoimmunity is not a mistaken reaction of the body against itself, but rather a disease of toxic exposures. In IBD, the gut wall is contaminated by toxicity generated by an unhealthy gut microbiome. The immune system uses powerful tools (inflammation, antibodies, etc) to remove this toxicity. The activity of the immune system creates symptoms of the disease. The GAPS Nutritional Protocol normalises the gut flora and allows the gut wall to cleanse and heal, removing the need for inflammation and other activities of the immune system. Our paper provides valuable insights into the current need for IBD treatments that tackle the true cause of the disease-abnormal gut flora. We hope this study will urge clinical practitioners to realise the central role gut dysbiosis plays in the onset of autoimmune diseases and their remission.
... Butyrate induces the differentiation of immune cells into T-regulatory cells (Tregs), which control inflammation [51]. The prevalence of inflammatory bowel disease (IBD) has increased over time closely in step with the rise in glyphosate usage on core crops [57]. Glyphosate was one of the toxic chemicals identified as a contributor to IBD in a recent publication by Chen et al. [58]. ...
... Acting as an endocrine disruptor, glyphosate can disrupt insulin signaling, leading to diabetes. Diabetes prevalence is rising in the United States in step with the rise in glyphosate usage on core crops [57]. Oral exposure of albino Wistar rats to glyphosate for 16 weeks was associated with a rise in fasting glucose and insulin, along with a drop in serum testosterone, and an increase in liver production of pro-inflammatory factors, including NF-κB, Il-6, Il-1β, and peroxisome proliferator-activated receptor-γ (PPAR-γ) [101]. ...
... PIN1 is normally expressed at very high levels in neurons, but it is inhibited in neurons in Alzheimer's disease via multiple mechanisms, including downregulation, oxidation, phosphorylation and sequestration [106]. Just as autism rates over time are highly correlated with glyphosate usage on core crops, age-adjusted deaths due to Alzheimer's disease over time had a correlation coefficient R of 0.917 with glyphosate usage on corn and soy crops in the United States, with a p-value of 2.2E-7 for the probability of a chance occurrence [57]. ...
... El glifosato y sus formulaciones comerciales, que son insoslayables al cultivo de la soya Roundup Ready, dañan el ADN y los cromosomas de células humanas y de animales (24) , y han sido asociados con trastornos endocrinos, neurológicos e intestinales (25) . La creciente prevalencia de Alzheimer, demencia senil, Parkinson, trastorno por déficit de atención con hiperactividad (TDAH) y autismo en Estados Unidos de América, también ha sido asociada con el mayor uso de glifosato durante largo tiempo (26) . En 2015, la Agencia Internacional de Investigación del Cáncer clasificó al glifosato como genotóxico y cancerígeno para animales y probablemente para humanos (grupo 2A) (27) . ...
Introducción.
El consumo de alimentos industrializados que contienen organismos genéticamente modificados (OGM) se ha incrementado notablemente. Desde su inicio ha generado crecientes controversias debido a que se considera de riesgo para la salud. En Perú se carece de información científica sobre los OGM en alimentos industrializados.
Objetivo.
Detectar y cuantificar molecularmente los indicadores de transgenicidad P35S y TNOS, y la soya transgénica Roundup Ready en alimentos industrializados de soya; y verificar su mención en la etiqueta.
Métodos.
Analizamos 30 muestras, para extraer el ADN utilizamos los kits Dneasy Mericon Food y Dneasy Power Soil. Para la detección y cuantificación de las secuencias transgénicas usamos la técnica PCR en tiempo real con los kits Mericon.
Resultados.
Detectamos transgenicidad en el 100% de las muestras y soya Roundup Ready en el 66,7%. El número de copias/mL o g de muestra osciló entre 1,21E+0 y 8,88E+7. En el etiquetado del 93,3% de las muestras no hubo referencia a componentes transgénicos.
Conclusión.
Los hallazgos evidencian la urgente necesidad de que la legislación vigente se actualice de acuerdo con los conocimientos científicos y el desarrollo socioeconómico del país, protegiendo la salud y el derecho a la información de la población.
... Foods subjected to genetic modification have been found to pose risk to the health of man due to the various diseases reported to be associated to such foods. The diseases include Acute kidney failure, Alzheimer's, diabetes, cancers of the thyroid/liver/bladder/pancreas/kidney, end-stage renal disease, hepatitis C, hormonal imbalances, hypertension, end-stage renal disease, lipoprotein metabolism disorder, myeloid leukemia, obesity, respiratory problems, stroke, and susceptibility to infection or immunosuppression [68][69][70][71]. ...
