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The goal of this systematic review was to explore emerging perspectives on the role of skin microbiota in acne vulgaris, skin aging, and rosacea. We searched the literature for published clinical trials, randomized controlled trials, cross-sectional studies, and cohort studies, both experimental and observational, whose primary main purpose was to...
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Citations
... Weng and Cheng [89] carried out a comprehensive review in which studies on the relationships between the skin microbiome and acne vulgaris, rosacea, and skin aging were included. Authors summarized that in acne Firmicutes spp., Proteobacteria spp., Actinobacteria spp., Staphylococcus spp., and Streptococcus spp. ...
... Authors summarized that in acne Firmicutes spp., Proteobacteria spp., Actinobacteria spp., Staphylococcus spp., and Streptococcus spp. were increased, while S. epidermidis were decreased [89]. ...
... Finally, the aforementioned review by Weng and Chen [89] described that, in papulopustular rosacea, the proportions of Firmicutes and Proteobacteria are higher and Actinobacteria proportions are lower. ...
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This review deals with the use of nutribiotics in skin care, which is of great interest as a nutritional supplement therapy in skin dysbiosis and related diseases.
Abstract
The study of the human microbiome has been a hot topic during the recent decades. More recently, the skin microbiome has attracted great interest as well. So, the scientific community has become interested in the role of the skin microbiome in skin health and its relationship with different disorders, such as atopic dermatitis, psoriasis, acne, and rosacea, among others. Numerous studies and investigations have been performed to study the role of pre- and probiotics as nutraceuticals in the treatment of skin diseases, with growing evidence over the recent ten years. This review gathers information on the use of “nutribiotics” in skin care health, focusing on the main dermatological diseases and other skin conditions. Clinical studies show that nutribiotics could be a new tool to improve skin health, and pre-, pro-, syn-, post-, and para-probiotics seem to be beneficial for several skin disorders as well as for repairing the skin barrier and promoting wound healing. In conclusion, the skin microbiome has become a new field with great potential to develop innovative products to manage skin health and diseases. Future advances in this field may facilitate the treatment of skin dysbiosis, with nutribiotics being a suitable method for skin care.
... Weng & Cheng [89] carried out a comprehensive review in which studies on the relationships between the skin microbiome and acne vulgaris, rosacea, and skin aging were included. Authors summarized that in acne Firmicutes spp., Proteobacteria spp., Actinobacteria spp., Staphylococcus spp., and Streptococcus spp. ...
... Authors summarized that in acne Firmicutes spp., Proteobacteria spp., Actinobacteria spp., Staphylococcus spp., and Streptococcus spp. they were increased, while S. epidermidis decreased [89]. ...
... Finally, the aforementioned review by Weng & Chen [89] described that, in the papulopustular rosacea, the proportions of Firmicutes and Proteobacteria are higher, and Actinobacteria proportions been lower. ...
The study of the human microbiome has been a hot topic during the last decades and more recently the skin microbiome has aroused great interest as well. So that, scientists have turned their attention to the role of the skin microbiome in skin health, and its relationship with different disorders as atopic dermatitis, psoriasis, acne, and rosacea, among others. Numerous studies and investigations have been performed to study the role of pre and probiotics as nutraceuticals in the treatment of skin diseases, with growing evidence along the last ten years. This review gathers information on the use of “nutribiotics” in skin care health, focus on the main dermatological diseases and other skin conditions. Clinical studies show that nutribiotics could be a new tool to improve skin health and pre, pro, syn, post and para-probiotics seem to be beneficial on several skin disorders, as well as repairing the skin barrier, or promoting wound healing. In conclusion, skin microbiome has emerged as a new field with high potential to develop disruptive solutions to manage skin health and disease. Future advances in this field may facilitate the treatment of skin dysbiosis being nutribiotics a suitable method for skin care.
... Upregulation of keratinocyte-derived toll-like receptor 2 and proteinase-activated receptor 2, increased expression of cathelicidin and its bioactive form LL-37, activation of T helper type 1 and T helper 17 lymphocytes with their related immune mediators are mainly responsible for the inflammatory background of the disease 4,14,15 . It has also been proposed that both skin and gut microbiota contribute to the pathogenesis of rosacea 16,17 . Inflammatory pathways seem to play a key role in the pathogenesis of rosacea. ...
Rosacea is a chronic inflammatory skin disease that is characterized by recurrent episodes of erythema, telangiectasia and papulopustular lesions. Although the pathogenesis is not well established, growing knowledge suggests that multiple etiological factors play a role resulting in inflammation. The aim of the present study is to investigate inflammatory status of patients with rosacea by evaluating CBC parameters and systemic immune inflammation (SII) index and compare these parameters with control group. Thus, it is aimed to understand the role of systemic inflammation in the pathogenesis of the disease. This retrospective, case–control study included 100 patients with rosacea and 58 sex- and age-matched controls. Laboratory examinations including CBC, ESR, CRP, HDL, LDL, and triglyceride levels were recorded and neutrophil–lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR), monocyte-to-high-density lipoprotein ratio (MHR) and SII index were calculated. Monocyte and platelet count, SII index, ESR and CRP were significantly higher in patients with rosacea than in the control group. No statistically significant difference was found in other parameters. There was no significant correlation between disease severity and ESR, CRP, and SII index. The findings of this study suggest that apart from the inflammatory pathways at the level of skin, there is an inflammatory state in the blood of patients. Rosacea is a skin disease, but it may have systemic implications and/or associations that need to be clarified completely.
... A prevalência e incidência dessa patologia em adultos vem aumentando nos últimos anos, principalmente em mulheres devido ao uso de maquiagem (9). Também faz parte de um problema secundário, pois as pessoas podem desenvolver depressão e ansiedade por causa de sua imagem (4,10). Existem dados que descrevem o custo dos tratamentos da acne na Alemanha, chegando a aproximadamente 400 milhões de euros por ano (11). ...
... acnes), por sua vez, o tratamento é direcionado aos cuidados com a pele com antimicrobianos tópicos/orais, peróxido do benzoíla e retinóides (7,12). Atualmente, há evidências que sugerem que existe mais de um microrganismo que atua como comensal e patógeno quando se fala em acne, como Staphylococcus epidermidis, que também está relacionado a outras patologias dermatológicas como dermatite e até rosácea (10,13). ...
Os seres humanos têm milhões de microrganismos em nossos corpos em simbiose, 20 milhões de genes microbianos foram identificados. A acne afeta entre 85% a 90% da população mundial que tem dietas ocidentais, isso por sua vez acarreta psicologicamente, doenças como depressão, ansiedade, etc. As bases etiológicas da doença são dadas pela família Cutibacterium acnes (Propionibacterium), mas o mecanismo não está tão claro. Atualmente, há evidências indicando que o Staphylococcus epidermidis da pele e também do microbioma intestinal estão envolvidos. Portanto, neste estudo, buscou-se o papel do microbioma intestinal e facial no desenvolvimento da acne vulgaris, bem como a atualização do mecanismo com base nos artigos mais recentes. Como conclusão e achados relevantes, foi visto que a inflamação da acne é dependente da homeostase intestinal, portanto o uso de probióticos reduz significativamente a inflamação das lesões de acne, além disso, os resultados dos tratamentos podem ser vistos após 2 semanas. Ademais, o uso de antibióticos deve ser evitado, pois reduzem o processo de cicatrização das lesões.
... However, little is known about its role in skin aging and esthetic medicine. In this issue of Dermatol Sinica, Weng and Chen [1] reviewed emerging perspectives on the role of the skin microbiota in acne vulgaris, skin aging, and rosacea from studies using 16s rRNA and metagenomics analyses, and suggested the potential development of therapies targeting the pathogenic strains of the skin microbiome involved in these skin problems. Zhang [2] identified several immune-associated genes associated with signal transduction, inflammatory response, immune response, and innate immune response in atopic dermatitis, contact dermatitis, and psoriasis, by single-sample gene set enrichment analysis and gene ontology biological process. ...
