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Amphiphilic copolymers (ACs) are versatile systems with self-assembling and aggregating properties, enabling the formation of nanomaterials (NMs) such as micelles, vesicles, nanocapsules, and nanogels. These materials have been extensively explored for the delivery of various drugs and active compounds, enhancing the solubility and permeation of po...
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... research has focused on developing AC NMs with controlled release mechanisms responsive to stimuli such as pH, temperature, and light (Figure 3). These systems can be combined with other cancer therapies, such as photothermal treatment, to enhance the effectiveness of apoptosis in cancer cells (Table 3). pH is a crucial factor for AC NMs because the extracellular environment of tumors is more acidic compared to normal tissue and blood (pH 7.4). ...Context 2
... example, hyaluronic acid (HA) conjugated with the hydrophobic moiety 5β-cholanic acid (5β-CA) self-assembled into HA-based NPs (HANPs) for controlled release of PTX against various skin cancer cell lines, including MDA-MB-435 melanoma, adenocarcinoma A549, and HepG2 cells [98]. Table 3. Recent application of the stimuli-responsive and synergic effect of AC NMs on skin cancer treatment. ...