Figure 3 - uploaded by Conchita Fraguas Bringas
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Conserved ACE2 and spike protein receptor binding domain (RBD) interactions in COVID-19 and Rs3367 SARS-like bat CoV. The Rs3367 RBD model was superimposed on the structure of ACE2 receptor complexed with COVID-19 (PDB 6LZG)(19) in Chimera (20). Conserved RBD residues are shown in neon green (Rs3367) and purple (COVID-19). ACE2 residues are shown in cyan.
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COVID-19 is a recently emerged coronavirus which binds angiotensin-converting enzyme 2 (ACE2) for cell entry via its receptor binding domain (RBD) on a surface-expressed spike glycoprotein. Recent studies show that despite its similarities to severe acute respiratory syndrome (SARS) coronavirus, there are critical differences in key RBD residues wh...
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