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In its Measure 17 (Theme 2), the EcoAntibio 2017 Plan provides for maintaining the MAs of older antibiotics regarded as non-critical for human medicine, and in particular focusing on revalidation of the therapeutic regimens. Feedback from use in the field indicates dosages that are ill suited to certain bacterial populations encountered in the targ...
Contexts in source publication
Context 1
... description of this phenomenon for the fluoroquinolones led to the concepts of mutant prevention concentration (MPC) and mutant selection window (MSW), which are illustrated by Figure 2 and described below. This phenomenon is applicable to antibiotics in which resistance appears by mutation. ...
Context 2
... on animal models, confirmed by clinical trials in humans, have shown that the values of the PK/PD indices must be higher when the objective is to maximise prevention of resistance. This amounts to saying that faced with high bacterial loads, higher doses that lead to concentrations well above the MIC of the majority wild population are needed to reduce the probability of selection of resistance in the pathogenic bacteria to be eradicated ( Figure 2). ...
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