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- Adolescent rats engage the orbitofrontal-striatal pathway differently than adults during impulsive actions

Chemogenetic manipulation of corticostriatal circuits. (A) Timeline of CRIT showing animals’ age at each stage for adolescents (top) and adults (bottom). Arrows represent days animals were injected with either saline or CNO. Created with Biorender.com. (B) CNO (10 mg/kg) treatment resulted in increased premature actions in both age groups during later sessions. (C) Number of premature actions is similar between adults and adolescents treated with CNO, but adolescent premature actions differ from adults across sessions following saline treatment. (D) CNO treatment resulted in reduced correct actions in both age groups. (E) Both adolescents and adults increase the number of correct actions across session. Data are presented as mean + SEM. *p < 0.05 main effect.
Chemogenetic manipulation of corticostriatal circuits. (A) Timeline of CRIT showing animals’ age at each stage for adolescents (top) and adults (bottom). Arrows represent days animals were injected with either saline or CNO. Created with Biorender.com. (B) CNO (10 mg/kg) treatment resulted in increased premature actions in both age groups during later sessions. (C) Number of premature actions is similar between adults and adolescents treated with CNO, but adolescent premature actions differ from adults across sessions following saline treatment. (D) CNO treatment resulted in reduced correct actions in both age groups. (E) Both adolescents and adults increase the number of correct actions across session. Data are presented as mean + SEM. *p < 0.05 main effect.
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