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In the present work, two types of potentiometric electrodes were constructed for determination of cetrimide. The sensors demonstrated advanced performances with a fast response time, a lower detection limit of 4.0×10 -6 M and potential responses across the range of 5.0×10 -6 -1.0×10 -3 M. The sensors enabled the cetrimide measurement in pharmaceuti...
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Potentiometric method for determination of Gemifloxacin (GEMI) by ion selective electrode based on ZnO nanorods incorporation with HPβ-CD as sensing ionophore and (KTFPB) potassium tetrakis-(3,5(Triflouromethyl) Phenyl Borate) ion as anionic site (additive) in Polyvinyl Chloride (PVC) membrane, without inner reference solution was developed. The se...
Abstract
Potentiometric determination of moxifloxacin (Moxi) by ion selective electrode based on ZnO nanorods
incorporation with HPβ-CD as sensing ionophore and (KTFPB) potassium tetrakis- (3,5(triflouromethyl) phenyl
borate ion as anionic site (additive) in polyvinyl chloride (PVC) membrane, without inner reference solution was
developed. The sens...
Citations
... The sensitivity and selectivity of ISE are known to be dependent not only on the nature of ionophores, but also significantly on the composition of the membrane ingredients. Therefore, it was of interest to study the effects of the membrane composition, ion exchange and type of plasticizer on the potential response of the proposed sensor [39] . Performance , response characteristics and results obtained over a period of 4 weeks for the investigated sensor are summarized in Table 2. ...
... Especial attention in drug analysis is paid on sensors based on plasticized polymeric PVC membranes. The most frequently used as solvent mediators to obtain different sensors are dioctyl phthalate [2][3][4][5][6][7], nitrobenzene and benzyl acetate [2,[7][8][9][10][11][12][13][14][15][16], dibutyl phthalate [5,[8][9][10][11][12][13][14][15][16][17], nitrophenyloctyl ether [3,11,13,[15][16][17][18][19][20], bis (2-ethylhexyl)sebacate [4,5,20,21]. Much less frequently do researchers use less common membrane-solvents like di-or tri-butyl phosphate [17] and 1-isopropyl-4-nitrobenzene [20]. ...
... Especial attention in drug analysis is paid on sensors based on plasticized polymeric PVC membranes. The most frequently used as solvent mediators to obtain different sensors are dioctyl phthalate [2][3][4][5][6][7], nitrobenzene and benzyl acetate [2,[7][8][9][10][11][12][13][14][15][16], dibutyl phthalate [5,[8][9][10][11][12][13][14][15][16][17], nitrophenyloctyl ether [3,11,13,[15][16][17][18][19][20], bis (2-ethylhexyl)sebacate [4,5,20,21]. Much less frequently do researchers use less common membrane-solvents like di-or tri-butyl phosphate [17] and 1-isopropyl-4-nitrobenzene [20]. ...
Background: The analytical characteristics of electrodes containing liquid PVC membrane depend on the purity of the electroactive material and the applied membrane solvents.Methods: Fluoxetine - one H-bond donor, formed ion-associated complexes with tetraphenylborate, tetrakis(4-chlorophenyl)borate and dipicrylamine. To confirm the quality and purity obtained complexes the elemental and TLC analysis were performed. The construction and general characteristics of fluoxetine ion-selective plastic membrane sensors, based on the use of a fluoxetine – tetrakis(4-chlorophenyl)borate ion-pair complex as electroactive material with 2-nitrophenyloctyl ether, bis(2-ethylhexyl)sebacate, bis(2-butylpentyl)adipate and 1-isopropyl-4-nitrobenzene as solvent mediators.Results: The electrode containing Fl-ClTPB-NPhOE (fluoxetine-tetrakis(4-chlorophenyl)borate-2-nitrophenyloctyl ether showed a linear response to fluoxetine at concentration ranges of 30.93 – 2.16 g·L-1 with a super Nernstian cationic slope 60.19 mV·decade-1.Conclusions: This Fl-ClTPB-NPhOE sensor was used for the potentiometric determination of the content of fluoxetine hydrochloride in pure form and pharmaceutical formula.
In this work, construction and analytical application of a new potentiometric PVC membrane sensor for the determination of Clomiphene are studied. The sensor respond based on ion-exchange mechanism between the organic layer of the membrane and aqueous phase. The proposed sensor showed a linear dynamic range between 8.0×10-6 and 1.0×10-2 mol L-1 of Clomiphene with a Nernstian slope of (57.6±0.6) mV decade-1 and a detection limit of 6.3×10-6 mol L-1. The best PVC membrane sensor response was obtained by a membrane composition of 30% PVC, 62% DBP, 6% ion-pair and 2% ionic liquid. The potentiometric response was independent to the solution pH in the range of 4.0 to 6.0. The proposed electrode displayed fast response time about 15 s, and it can be used for a period of six weeks without any considerable change in its performance. Application of this potentiometric sensor for the Clomiphene determination in some pharmaceutical formulations was satisfactory result.
In this work, potentiometry was used for the determination of Terbinafine which is one of the antifungal drugs. The indicator electrode used in the potentiometric method was a kind of PVC membrane sensor. The sensing element of the PVC membrane was made from the interaction of Terbinafine hydrochloride and sodium tetraphenyl borate. The electrode respond based on the ion-exchange mechanism. The best PVC membrane sensor was composed of 30% PVC, 62% DBP, 6% ion-pair and 2% ionic liquid. The response of the sensor was about 15 s and the Nernstian slope of the calibration curve was 57.8±0.4 mV per decade. The lifetime of the sensor was obtained 6 weeks. The proposed method was successfully applied in the determination of Terbinafine in the pharmaceutical formulations.
PVC membrane potentiometric sensor was made for determination of Clonidine in pharmaceutical formulations. The electrode respond based on ion-exchange mechanism. The ion-pair used as a sensing element in PVC membrane composition was synthesized by interaction of Clonidine hydrochloride and tetraphenyl borate. The best PVC membrane sensor response was obtained by a membrane composition of 30% PVC, 62% DBP, 6% ion-pair and 2% ionic liquid. The proposed method was successfully applied in determination of Clonidine in some formulations. The proposed sensor showed a linear dynamic range between 7.0x10(-6)-1.0x10(-2) M of Clonidine with a Nernstian slope of (58.3+/-0.4) mV decade(-1) and a detection limit of 6.5x10(-6) M. The proposed electrode displayed fast response time about 10 s, and lifetime of about six weeks without any significant change in its performance.
