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The remarkable therapeutic properties of Nigella sativa, often known as black seed or kalonji are well recognized. The use of N. sativa seeds and its oil has a long history in various traditional food and medical systems. As stated by the holy prophet of Islam (PBUH), Shoneez is important since it can cure all diseases with the exception of death....
Citations
... N. sativa's exceptional therapeutic potential makes it one among the best-rated evidence-based herbal remedies. Most of the essential oil's therapeutic properties are attributed to thymoquinone, which is its primary bioactive ingredient (Alam et al.,2023). ...
... However, the components in oil may induce antioxidative-induced prooxidant effects thus the carcinogenetic effect (Khalife et al., 2016). Numerous processes evaluated by (Alam et al., 2023) highlight the anti-proliferative, pro-apoptotic, antioxidant, cytotoxic, anti-mutagenic, and anti-metastatic properties of Nigella sativa. Black seed oil has the potential to be used in immune therapy since it stimulates NK cells. ...
... The seeds of N. sativa have been utilized traditionally in North Africa for the treatment of various gastrointestinal disorders, including stomach ulcers. The therapeutic effects of N. sativa have been attributed to its various bioactive compounds, such as thymoquinone, thymohydroquinone, and thymol (Alam et al. 2023). Thymoquinone, a major active component of N. sativa, has been demonstrated to exhibit anti-ulcer activity in several experimental models of gastric ulceration. ...
Peptic ulcer disease remains a prevalent gastrointestinal disorder worldwide. Current treatments often have limitations, sparking interest in alternative therapies from medicinal plants. This review examines the gastroprotective potential of 54 North African medicinal plants against peptic ulcers. An extensive literature search was conducted, focusing on plants with preclinical and clinical evidence of anti‐ulcer efficacy and documented use in North African traditional medicine. The review identified several promising plant species, such as licorice (Glycyrrhiza glabra), chamomile (Matricaria chamomilla), olive (Olea europaea), pomegranate (Punica granatum), Aloe vera, and black seed (Nigella sativa), along with their bioactive constituents, including flavonoids, tannins, and terpenoids. These compounds exhibit gastroprotective properties through multiple mechanisms, such as enhancing the gastric mucosal barrier, inhibiting acid secretion, displaying antioxidant and anti‐inflammatory effects, promoting ulcer healing, and combating Helicobacter pylori infection. The evidence presented includes in vitro assays, animal models, and some clinical studies. While many of the 53 plants reviewed demonstrated significant anti‐ulcer effects compared to standard drugs, further clinical research is needed to establish efficacy and safety in humans. The synergistic actions of phytochemical mixtures in medicinal plant extracts likely contribute to their therapeutic potential. This review highlights the role these North African medicinal plants may play in the prevention and treatment of peptic ulcers and identifies promising candidates for further research and development of evidence‐based botanical therapies.
