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Figure 4 - Dynamics of transcriptional regulation from total RNA-seq experiments

Figure 4 Characterization of steady-state RNA dynamics: reanalysis of 620 RNA-seq datasets. (A) Median abundances of premature and mature RNAs per gene were compared for protein-coding (top panel), pseudo-(middle) and long non-coding genes (bottom). Density scatter plot were fitted with a linear model, whose slope is reported. (B) Heatmaps displaying the degree of post-transcriptional regulation for each gene (row) in each sample (column). The ratio between premature and mature RNA abundance for each genes in each sample were determined and compared to the global trend depicted in (A). Each gene is either not expressed (blue), not differentially post-transcriptional regulated (white; ratio between the dashed lines in (A)), or differentially post-transcriptional regulated (red; ratio above the dashed lines). Above the heatmaps, two colourbars indicate the tissue-type and disease conditions of each sample.
Characterization of steady-state RNA dynamics: reanalysis of 620 RNA-seq datasets. (A) Median abundances of premature and mature RNAs per gene were compared for protein-coding (top panel), pseudo-(middle) and long non-coding genes (bottom). Density scatter plot were fitted with a linear model, whose slope is reported. (B) Heatmaps displaying the degree of post-transcriptional regulation for each gene (row) in each sample (column). The ratio between premature and mature RNA abundance for each genes in each sample were determined and compared to the global trend depicted in (A). Each gene is either not expressed (blue), not differentially post-transcriptional regulated (white; ratio between the dashed lines in (A)), or differentially post-transcriptional regulated (red; ratio above the dashed lines). Above the heatmaps, two colourbars indicate the tissue-type and disease conditions of each sample.
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