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Figure 2 - A census of cell types and paracrine interactions in colorectal cancer

Figure 2: Cell type census in normal colon and CRC. A UMAPs of epithelial, immune and stromal cells, separated by tissue of origin. Color code for cell type assignment. B Relative fractions of epithelial, immune and stromal cell types across all patient-derived libraries. For fractions per patient, see Supplementary Figure 3. C Single cell gene activities of stem cell marker OLFM4, proliferative marker MKI67, differentiated absorptive cell marker FABP1, and secretory cell marker TFF3. D Immunofluorescence analysis for OLFM4, MKI67, FABP1, and TFF3 in normal and tumor tissue. All sections are from patient P009, except the EPCAM/OLFM4 co-staining that was done on tumor tissue of P016. Scale bars indicate 100µm. E Relative fraction of TC1-5 in the tumor tissues of the patients. F Transcriptome-inferred cell-cycle distribution in the tumor cell fractions TC1-TC5 (bar graph), and in the UMAPs of normal and tumor epithelium.
Cell type census in normal colon and CRC. A UMAPs of epithelial, immune and stromal cells, separated by tissue of origin. Color code for cell type assignment. B Relative fractions of epithelial, immune and stromal cell types across all patient-derived libraries. For fractions per patient, see Supplementary Figure 3. C Single cell gene activities of stem cell marker OLFM4, proliferative marker MKI67, differentiated absorptive cell marker FABP1, and secretory cell marker TFF3. D Immunofluorescence analysis for OLFM4, MKI67, FABP1, and TFF3 in normal and tumor tissue. All sections are from patient P009, except the EPCAM/OLFM4 co-staining that was done on tumor tissue of P016. Scale bars indicate 100µm. E Relative fraction of TC1-5 in the tumor tissues of the patients. F Transcriptome-inferred cell-cycle distribution in the tumor cell fractions TC1-TC5 (bar graph), and in the UMAPs of normal and tumor epithelium.
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