Figure 4 - Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia

Brain activations and deactivations associated with the main effect of pain in each group in MRI Session B. Top, In all four groups, there was significant activation in the SI corresponding to the stimulation site, thalamus, cerebellum, midcingulate cortex, anterior/posterior insula, frontal operculum, SII, and SMA. Significant deactivations were detected in the mPFC, PCC/precuneous, and superior (S) frontal gyrus in all four groups. Bottom, Group comparisons revealed significantly greater activation in the left DLPFC in the placebo, sham mindfulness meditation, and control group compared with the mindfulness meditation group. Slice locations correspond to standard stereotaxic space.

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Reference

Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/Brain-activations-and-deactivations-associated-with-the-main-effect-of-pain-in-each-group_fig4_284196218 [accessed 26 Mar 2025]

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Figure 4. Brain activations and deactivations associated with the main effect of pain in each group in MRI Session B. Top, In all four groups, there was significant activation in the SI corresponding to the stimulation site, thalamus, cerebellum, midcingulate cortex, anterior/posterior insula, frontal operculum, SII, and SMA. Significant deactivations were detected in the mPFC, PCC/precuneous, and superior (S) frontal gyrus in all four groups. Bottom, Group comparisons revealed significantly greater activation in the left DLPFC in the placebo, sham mindfulness meditation, and control group compared with the mindfulness meditation group. Slice locations correspond to standard stereotaxic space.

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<a href="https://www.researchgate.net/figure/Brain-activations-and-deactivations-associated-with-the-main-effect-of-pain-in-each-group_fig4_284196218"><img src="https://www.researchgate.net/profile/Fadel_Zeidan/publication/284196218/figure/fig4/AS:299131248627715@1448329855658/Brain-activations-and-deactivations-associated-with-the-main-effect-of-pain-in-each-group.png" alt="Brain activations and deactivations associated with the main effect of pain in each group in MRI Session B. Top, In all four groups, there was significant activation in the SI corresponding to the stimulation site, thalamus, cerebellum, midcingulate cortex, anterior/posterior insula, frontal operculum, SII, and SMA. Significant deactivations were detected in the mPFC, PCC/precuneous, and superior (S) frontal gyrus in all four groups. Bottom, Group comparisons revealed significantly greater activation in the left DLPFC in the placebo, sham mindfulness meditation, and control group compared with the mindfulness meditation group. Slice locations correspond to standard stereotaxic space."/></a>