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Benign solid thyroid nodule shows rapid wash-out curve in contrast enhanced ultrasound (CEUS).  

Benign solid thyroid nodule shows rapid wash-out curve in contrast enhanced ultrasound (CEUS).  

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Fig. 1: Hypoechoic, inhomogenous solid thyroid nodule with enlarged AP...
Fig. 2: Colour Doppler image of malignant thyroid nodule show increased...
Fig. 3: Malignant Thyroid nodule (papillary carcinoma) show slow...
Fig. 4: Benign hypoechoic, well circumscribed solid thyroid nodule with...
+3 Fig. 5: Benign well circumscribed solid thyroid nodule with peripheral...
Contrast enhanced ultrasound in diagnosis of solitary thyroid nodules, preliminary study on papillary cancer
Conference Paper
Full-text available
  • Mar 2016
Purpose: To find out the ability of contrast enhanced ultrasound to differentiate malignant from benign thyroid nodules. Methods and Materials: Thirty five patients with solitary thyroid nodules (17 malignant, 18 benign) were included. All patients underwent contrast enhanced ultrasound examination and nodule morphologic verification - histological...
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Diagnostic performance of thyroid imaging reporting and data system (TI-RADS) alone and in combination with contrast-enhanced ultrasonography for the characterization of thyroid nodules
Article
  • Oct 2018
Background: The thyroid imaging reporting and data system (TI-RADS), classified and determined the risk of thyroid nodule malignancy with ultrasound scanning. Contrast-enhanced ultrasound (CEUS) is newly developed methods which could measure perfusion features. Objective: The aim of the study was to investigate the value of diagnosing thyroid nodules using TI-RADS combined with CEUS and determine whether improvements were made to the diagnostic accuracy. Methods: The features of conventional ultrasonography (US) and CEUS ion 117 case of thyroid nodules samples, which were confirmed by fine-needle aspiration and/or surgery, were retrospectively analyzed. The independent US and CEUS predictors for malignancy were determined and quantified using logistic regression analysis. The receiver operating characteristic (ROC) curve analysis was used to compare the diagnostic efficiency of each method in predicting malignant solid thyroid nodules. Results: The TI-RADS + CEUS combination had the highest accuracy (94.02%), sensitivity (94.74%), specificity (93.33%), PPV (93.10%) and NPV (94.92%), significantly greater than that of TI-RADS alone and CEUS alone (χ2 = 8.746, P < 0.001; χ2 = 9.825, P < 0.001). The area under the ROC curve (AUC) of TI-RADS alone, CEUS alone, and combined use of TI-RADS and CEUS were 0.871, 0.884, and 0.942, respectively. The following conventional US and CEUS features based on logistic regression analysis showed significant predictive value for thyroid malignant nodules: Obscure margin, calcification, hypoechoic, low enhancement, rim-like enhancement. Conclusions: TI-RADS in combination with CEUS has superior diagnostic efficiency in the discrimination of benign and malignant thyroid lesions, compared with TI-RADS and CEUS alone.
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