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Baseline cognition as a function of the polygenic risk scores of CSF ADAM22. Polygenic risk scores (PRS) of ADAM22 (n = 83) were calculated using genotyping data, which were measured by Omni2.5 M-8 array and filtered using PLINK toolset, contrasted with cognitive performance assessed over a period of 7 years using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), adjusted for age, sex and years of education. A illustrated the immediate memory index score, B the delayed memory index score, C visuospatial-constructional memory index score, D language index score, E attention index score, and F the total scale index score. Significant linear regressions are represented with a gray confidence region of the fitted line. Individual R squares and P values are shown in the top left corners of each figure. R squares are adjusted for the number of independent variables in the model.
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Cognitive dysfunction in Alzheimer’s disease (AD) correlates closely with pathology in the neuronal microtubule-associated protein tau. Tau pathology may spread via neural synapses. In a population of cognitively unimpaired elderly at elevated risk of AD, we investigated four cerebrospinal (CSF) markers of synaptic dysfunction and degeneration. Thr...
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... synaptic proteins of interest and contrasted this with baseline cognitive performance. These analyses used multiple linear regression models, adjusted for education in years as well as age, sex, and APOE ε4 status. Of all the synaptic proteins considered, only PRS for the post-synaptic ADAM22 pQTL was found to correlate with the RBANS total score (Fig. 5F, R 2 = 0.227, p = 0.00701) and its immediate memory subscale (Fig. 5A, R 2 = 0.143, p = 0.00397), delayed memory subscale (Fig. 5B, R 2 = 0.0744, p = 0.00583), and visuospatial-constructional memory subscale (Fig. 5C, R 2 = 0.275, p = 0.00735),. Conversely, ADAM23, SYT1, and SNAP25, which are presymptomatic markers, did not show any ...
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... performance. These analyses used multiple linear regression models, adjusted for education in years as well as age, sex, and APOE ε4 status. Of all the synaptic proteins considered, only PRS for the post-synaptic ADAM22 pQTL was found to correlate with the RBANS total score (Fig. 5F, R 2 = 0.227, p = 0.00701) and its immediate memory subscale (Fig. 5A, R 2 = 0.143, p = 0.00397), delayed memory subscale (Fig. 5B, R 2 = 0.0744, p = 0.00583), and visuospatial-constructional memory subscale (Fig. 5C, R 2 = 0.275, p = 0.00735),. Conversely, ADAM23, SYT1, and SNAP25, which are presymptomatic markers, did not show any associations with their corresponding polygenic risk score (data not ...
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... models, adjusted for education in years as well as age, sex, and APOE ε4 status. Of all the synaptic proteins considered, only PRS for the post-synaptic ADAM22 pQTL was found to correlate with the RBANS total score (Fig. 5F, R 2 = 0.227, p = 0.00701) and its immediate memory subscale (Fig. 5A, R 2 = 0.143, p = 0.00397), delayed memory subscale (Fig. 5B, R 2 = 0.0744, p = 0.00583), and visuospatial-constructional memory subscale (Fig. 5C, R 2 = 0.275, p = 0.00735),. Conversely, ADAM23, SYT1, and SNAP25, which are presymptomatic markers, did not show any associations with their corresponding polygenic risk score (data not ...
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... all the synaptic proteins considered, only PRS for the post-synaptic ADAM22 pQTL was found to correlate with the RBANS total score (Fig. 5F, R 2 = 0.227, p = 0.00701) and its immediate memory subscale (Fig. 5A, R 2 = 0.143, p = 0.00397), delayed memory subscale (Fig. 5B, R 2 = 0.0744, p = 0.00583), and visuospatial-constructional memory subscale (Fig. 5C, R 2 = 0.275, p = 0.00735),. Conversely, ADAM23, SYT1, and SNAP25, which are presymptomatic markers, did not show any associations with their corresponding polygenic risk score (data not ...
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... synaptic proteins of interest and contrasted this with baseline cognitive performance. These analyses used multiple linear regression models, adjusted for education in years as well as age, sex, and APOE ε4 status. Of all the synaptic proteins considered, only PRS for the post-synaptic ADAM22 pQTL was found to correlate with the RBANS total score (Fig. 5F, R 2 = 0.227, p = 0.00701) and its immediate memory subscale (Fig. 5A, R 2 = 0.143, p = 0.00397), delayed memory subscale (Fig. 5B, R 2 = 0.0744, p = 0.00583), and visuospatial-constructional memory subscale (Fig. 5C, R 2 = 0.275, p = 0.00735),. Conversely, ADAM23, SYT1, and SNAP25, which are presymptomatic markers, did not show any ...
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... performance. These analyses used multiple linear regression models, adjusted for education in years as well as age, sex, and APOE ε4 status. Of all the synaptic proteins considered, only PRS for the post-synaptic ADAM22 pQTL was found to correlate with the RBANS total score (Fig. 5F, R 2 = 0.227, p = 0.00701) and its immediate memory subscale (Fig. 5A, R 2 = 0.143, p = 0.00397), delayed memory subscale (Fig. 5B, R 2 = 0.0744, p = 0.00583), and visuospatial-constructional memory subscale (Fig. 5C, R 2 = 0.275, p = 0.00735),. Conversely, ADAM23, SYT1, and SNAP25, which are presymptomatic markers, did not show any associations with their corresponding polygenic risk score (data not ...
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... models, adjusted for education in years as well as age, sex, and APOE ε4 status. Of all the synaptic proteins considered, only PRS for the post-synaptic ADAM22 pQTL was found to correlate with the RBANS total score (Fig. 5F, R 2 = 0.227, p = 0.00701) and its immediate memory subscale (Fig. 5A, R 2 = 0.143, p = 0.00397), delayed memory subscale (Fig. 5B, R 2 = 0.0744, p = 0.00583), and visuospatial-constructional memory subscale (Fig. 5C, R 2 = 0.275, p = 0.00735),. Conversely, ADAM23, SYT1, and SNAP25, which are presymptomatic markers, did not show any associations with their corresponding polygenic risk score (data not ...
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... all the synaptic proteins considered, only PRS for the post-synaptic ADAM22 pQTL was found to correlate with the RBANS total score (Fig. 5F, R 2 = 0.227, p = 0.00701) and its immediate memory subscale (Fig. 5A, R 2 = 0.143, p = 0.00397), delayed memory subscale (Fig. 5B, R 2 = 0.0744, p = 0.00583), and visuospatial-constructional memory subscale (Fig. 5C, R 2 = 0.275, p = 0.00735),. Conversely, ADAM23, SYT1, and SNAP25, which are presymptomatic markers, did not show any associations with their corresponding polygenic risk score (data not ...
